综合认知障碍训练联合补充ω-3鱼油脂肪乳对卒中后认知障碍及血浆多不饱和脂肪酸水平影响  

Effects of Comprehensive Cognitive Impairment Training Combined with Omega-3 Fish Oil Fat Milk on Post-stroke Cognitive Impairment and Plasma Polyunsaturated Fatty Acid Levels

作　　者：李欣 莫非[1] LI Xin MO Fei(Department of Rehabilitation Medicine,Jiangsu Provincial Government Hospital,Nanjing Jiangsu,210000,China)

机构地区：[1]江苏省省级机关医院康复医学科,江苏南京210000

出　　处：《中华养生保健》2022年第21期9-13,共5页CHINESE HEALTH CARE

摘　　要：目的观察综合认知障碍训练联合补充ω-3鱼油脂肪乳治疗卒中后认知障碍(post-stroke cognitive impairment,PSCI)的临床疗效及对血浆多不饱和脂肪酸水平的影响。方法选取2019年1月~2022年3月在江苏省级机关医院住院的PSCI患者60例,按照随机数表法分为治疗组和对照组,每组30例。对照组给予综合认知障碍训练及口服多奈哌齐片基础康复及药物治疗,治疗组在对照组基础上增加ω-3鱼油脂肪乳注射液静脉注射100 mL/d,治疗1次/d,7次/周,连续治疗3周。比较治疗前后两组简明精神状态量表(Mini-mental State Examination,MMSE)评分、蒙特利尔认知测试(Montreal Cognitive Assessment,MoCA)评分、改良Barthel指数(modified Barthel index,MBI)评分、ω-3多不饱和脂肪酸(omega-3polyunsaturated fatty acid,ω-3PUFA)水平。结果治疗后,治疗组患者MMSE评分、MoCA评分高于对照组,差异有统计学意义(P<0.05);治疗后,治疗组MBI评分高于对照组,差异有统计学意义(P<0.05);治疗后,治疗组患者的ω-3PUFA(EPA、DHA)水平高于对照组,差异有统计学意义(P<0.05),ω-3PUFA(ALA)水平未有明显改善(P>0.05)。结论综合认知障碍训练联合补充ω-3鱼油脂肪乳可以更快改善PSCI患者的认知功能,提高日常生活能力,值得临床应用。Objective To observe the combined supplement of comprehensive cognitive impairment trainingω-3.The clinical efficacy of fish oil fat emulsion in the treatment of post stroke cognitive impairment(PSCI)and its effect on the level of plasma polyunsaturated fatty acids.Methods 60 patients with PSCI who were hospitalized in the rehabilitation department of Jiangsu provincial government hospital from January 2019 to March 2022 were randomly divided into treatment group and control group according to the random number table method.There were 30 patients in both groups.The control group was given comprehensive cognitive impairment training,basic rehabilitation and drug treatment with donepezil tablets.The treatment group was increased on the basis of the control groupω-3 fish oil fat emulsion injection was injected intravenously with 100 mL/d,once a day,seven times a week,for 3 weeks.Comparison of Mini-mental State Examination(MMSE),Montreal Cognitive Assessment(MoCA),modified Barthel index(MBI),omega-3 polyunsaturated fatty acids before and after treatment(omega-3polyunsaturated fatty acid,omega-3PUFA)levels.Results After treatment,MMSE score and MoCA score in the treatment group were higher than those in the control group,the diff erence was statistically significant(P<0.05);After treatment,the MBI score of the treatment group was higher than that of the control group,the diff erence was statistically significant(P<0.05);Patients in the treatment group after treatment the level ofω-3 PUFA was significantly higher than that of the control group,the diff erence was statistically significant(P<0.05).Conclusion comprehensive cognitive impairment training combined with Supplementω-3 fish oil fat emulsion can improve cognitive function and ADL of PSCI patients faster,which is worthy of further clinical recommendation.

关 键 词：卒中后认知障碍 综合认知康复训练 Ω-3多不饱和脂肪酸 简明精神状态量表 蒙特利尔认知测试 改良BARTHEL指数 

分 类 号：R459.3[医药卫生—治疗学]