皮层扩散性抑制的研究进展  

Research Progress of Cortical Spreading Depression

作　　者：赵博 禹爱梅[2] 邹玉安[2] ZHAO Bo;YU Ai-mei;ZOU Yu-an(Graduate School,Hebei North University,Zhangjiakou,075000,China;The First Affiliated Hospital of Hebei North University,Zhangjiakou,075000,China)

机构地区：[1]河北北方学院研究生学院,张家口075000 [2]河北北方学院附属第一医院神经内科,张家口075000

出　　处：《神经药理学报》2022年第3期28-33,共6页Acta Neuropharmacologica

摘　　要：皮质扩散性抑制(cortical spreading depression,CSD)是大脑皮质受刺激后产生的电活动抑制带,该抑制带可以将大脑皮质跨膜离子的浓度梯度迅速摧毁并去极化,导致细胞内外发生短路,可以影响大脑的灌注及代谢,导致不良预后,该文将从以下几个方面对CSD的研究进展进行综述。Cortical spreading depression is an inhibitory band of electrical activity generated after the cerebral cortex is stimulated.This inhibitory band can rapidly destroy and depolarize the concentration gradient of transmembrane ions in the cerebral cortex,resulting in short circuits inside and outside cells,which can affect brain perfusion and metabolism.resulting in a poor prognosis.This paper will summarize the research progress of CSR from the following aspects.

关 键 词：皮层扩散性抑制 去极化 低灌注 

分 类 号：R964[医药卫生—药理学]