基于“标本根结”理论揿针治疗干眼:随机对照试验  

Thumb-tack needle based on Biaoben Genjie theory for dry eye: a randomized controlled trial

作　　者：周婷 朱丹 许辛寅 罗志辉[1] 顾骁磊 陈佳 陈子琴 陈贝 张艳琳 王昆秀 闫鹏 陈松 ZHOU Ting;ZHU Dan;XU Xin-yin;LUO Zhi-hui;GU Xiao-lei;CHEN Jia;CHEN Zi-qin;CHEN Bei;ZHANG Yan-lin;WANG Kun-xiu;YAN Peng;CHEN Song(College of Acupuncture and Orthopedics,Hubei University of CM,Wuhan 430061,China;Department of Ophthalmology,Hubei Provincial Hospital of TCM;Department of Acupuncture and Moxibustion,Hubei Provincial Hospital of TCM;Department of Rehabilitation,Jingzhou Second People's Hospital;Salt in Jintan Salt Limited Liability Company in Post-doctoral Research Station,Shanghai 213200;College of Humanities Post-doctoral Station,Xiamen University,Xiamen 361005,Fujian Province)

机构地区：[1]湖北中医药大学针灸骨伤学院,武汉430061 [2]湖北省中医院眼科 [3]湖北省中医院针灸科 [4]荆州市第二人民医院康复科 [5]中盐金坛盐化有限责任公司博士后科研工作站,上海213200 [6]厦门大学人文学院博士后流动站,福建厦门361005

出　　处：《中国针灸》2022年第10期1120-1124,共5页Chinese Acupuncture & Moxibustion

基　　金：湖北省中医院院内项目:2021YJKT-20;国家中医药管理局全国名老中医药专家传承工作室建设项目:国中医药人教函[2022]75号;国家中医药管理局第七批全国老中医药专家学术经验继承工作:国中医药人教函[2022]76号;中医药传承与创新“百千万”人才工程(岐黄工程):国中医药人教函[2018]284号。

摘　　要：目的:比较揿针埋针与玻璃酸钠滴眼液治疗干眼的临床疗效。方法:将60例干眼患者随机分为揿针组和西药组,各30例。揿针组基于“标本根结”理论选取至阴、厉兑、跗阳、养老、睛明、攒竹行揿针埋针治疗,每周2次;西药组采用0.1%玻璃酸钠滴眼液治疗,每日3次,均治疗4周。分别于治疗前后观察两组患者中医症状评分、泪膜破裂时间(BUT)、泪液分泌试验(SⅠT)、角膜荧光素钠染色(FL)评分、健康调查简表(SF-36)评分,并评定两组临床疗效。结果:治疗后,两组患者各项中医症状评分及总分均较治疗前降低(P<0.05);除视物疲劳、畏光症状评分外,揿针组患者各项中医症状评分及总分均低于西药组(P<0.05)。治疗后,两组患者BUT延长、SⅠT增加、FL评分降低、SF-36评分增加(P<0.05);揿针组患者BUT、SⅠT、SF-36评分高于西药组(P<0.05),FL评分低于西药组(P<0.05)。揿针组总有效率为93.3%(28/30),高于西药组的80.0%(24/30,P<0.05)。结论:基于“标本根结”理论的揿针埋针治疗可有效缓解干眼患者临床症状,延长泪膜破裂时间,增加泪液分泌量,提高泪膜功能及患者生活质量,疗效优于玻璃酸钠滴眼液治疗。Objective To compare the clinical efficacy of thumb-tack needle and sodium hyaluronate eye drops for dry eye. Methods A total of 60 patients with dry eye were randomly divided into a thumb-tack needle group and a western medication group, 30 cases in each group. Based on Biaoben Genjie theory, thumb-tack needle was applied at Zhiyin(BL 67),Lidui(ST 45), Fuyang(BL 59), Yanglao(SI 6), Jingming(BL 1) and Cuanzhu(BL 2) in the thumb-tack needle group, 2 times a week. In the western medication group, 0.1% sodium hyaluronate eye drops were applied, 3 times a day. Both groups were treated for 4 weeks. Before and after treatment, TCM symptom score, tear film break-up time(BUT), SchirmerⅠtest(SⅠT),corneal fluorescein sodium staining(FL) score and 36-item short form health survey(SF-36) score were observed, and the clinical efficacy was evaluated in the two groups. Results After treatment, the total scores and each item score of TCM symptom in the two groups were decreased compared with before treatment(P<0.05);except for score of visual fatigue and photophobia, the total score and each item score of TCM symptom in the thumb-tack needle group were lower than the western medication group(P<0.05). After treatment, the BUT, SⅠT and SF-36 scores were increased and the FL scores were decreased in the two groups(P<0.05);the BUT, SⅠT and SF-36 score were higher than the western medication group(P<0.05), and the FL score was lower than the western medication group(P<0.05) in the thumb-tack needle group. The total effective rate in the thumb-tack needle group was 93.3%(28/30), which was higher than 80.0%(24/30) in the western medication group(P<0.05). Conclusion Thumb-tack needle based on Biaoben Genjie theory could effectively relieve clinical symptoms of dry eye patients, prolong tear film break-up time, increase tear secretion, improve tear film function and quality of life, and its curative effect is better than sodium hyaluronate eye drops.

关 键 词：干眼 揿针 标本根结 玻璃酸钠滴眼液 泪膜功能 生活质量 随机对照试验 

分 类 号：R246.82[医药卫生—针灸推拿学]