肠三叶因子对脓毒症患者急性胃肠损伤的早期预测价值  

The early predictive value of intestinal trefoil factor for acute gastrointestinal injury in patients with sepsis

作　　者：李文俊 汪海华 LI Wenjun;WANG Haihua(Department of Clinical laboratory,Honghu People’s Hospital,Hubei,Honghu 433200,China)

机构地区：[1]湖北省洪湖市人民医院检验科,433200

出　　处：《河北医药》2022年第19期2950-2952,2956,共4页Hebei Medical Journal

摘　　要：目的探讨肠三叶因子对脓毒症患者急性胃肠损伤的早期预测价值。方法收集2020年3月至2021年3月治疗的152例脓毒症患者为研究对象,根据患者住院治疗期间是否并发急性胃肠损伤分为80例急性胃肠损伤组(研究组)和72例非急性胃肠损伤组(对照组)。收集患者临床资料,所有患者均于入院时24 h内空腹抽取肘静脉血5 ml,采用酶联免疫吸附双抗体夹心法检测血清(intestinal trefoil factor,TFF3)、C-反应蛋白(C-reactionprotein,CRP)水平,并绘制相应ROC曲线。结果2组患者性别比、年龄、体重指数、呼吸频率、心率、感染部位、机械通气时间、ICU时间等方面比较,差异无统计学意义(P>0.05);其中研究组在APACHEⅡ评分、SOFA评分、血清TFF3、CRP水平明显高于对照组(P<0.05);Logistic回归分析显示,APACHEⅡ评分、CRP、TFF3是影响脓毒症患者急性胃肠损伤的独立危险因素(P<0.05)。ROC曲线分析显示,血清TFF3对预测脓毒症患者急性胃肠损伤的AUC为0.941,最佳临界值为12.76μg/L,敏感度为82.50%,特异度为90.28%;相关性分析显示,急性胃损伤患者血清TFF3与CRP、APACHEⅡ评分呈显著正相关关系(r=0.728、0.763,P<0.05)。结论脓毒症患者并发早期急性胃损伤血清TFF3升高,可以作为脓毒症急性胃肠酸的血清生物标志物之一。Objective To investigate the early predictive value of intestinal trefoil factor for acute gastrointestinal injury in patients with sepsis.Methods A total of 152 patients with sepsis who were treated in our hospital from March 2020 to March 2021 were enrolled in the study,who were divided into research group(acute gastrointestinal injury,n=80)and control group(non-acute gastrointestinal injury,n=72).The clinical data of patients were collected,and the serum levels of intestinal trefoil factor(TFF3)and C-reaction protein(CRP)were detected by ElASA(double antibody sandwich method),and corresponding ROC curve was drawn.Results There were no significant differences in patient’s gender and age,BMI,respiratory rate,heart rate,infection site,mechanical ventilation time and ICU time between the two groups(P>0.05).However the APACHEⅡscores,SOFA scores,serum TFF3 and CRP levels in research group were significantly higher than those in control group(P<0.05).Logistic regression analysis showed that APACHEⅡscore,CRP and TFF3 were independent risk factors affecting acute gastrointestinal injury in patients with sepsis(P<0.05).ROC curve analysis showed that the AUC of serum TFF3 for predicting acute gastrointestinal injury in patients with sepsis was 0.941,the best cut-off value was 12.76μg/L,the sensitivity and specificity were 82.50%,90.28%,respectively.The correlation analysis showed that there was a significant positive correlation between serum TFF3 and CRP and APACHEⅡscores in patients with acute gastric injury(P<0.05).Conclusion The serum levels of TFF3 are increased in patients with sepsis complicated by early acute gastric injury,which can be regarded as one of the serum biomarkers of acute gastrointestinal injury in patients with sepsis.

关 键 词：肠三叶因子 脓毒症 急性胃肠损伤 预测价值 

分 类 号：R446.112[医药卫生—诊断学]