普列克底物蛋白同源结构域家族A成员1蛋白在肿瘤中的研究进展  

Research Progress of Pleckstrin Homology Like Domain Family A Member 1 in Tumor

作　　者：赵士博 马汉俊 吴忠港 凌博 叶广彬 ZHAO Shibo;MA Hanjun;WU Zhonggang;LING Bo;YE Guangbin(School of Clinical Medicine,Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China;School of Pharmacy,Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China;School of Basic Medical Sciences,Youjiang Medical University for Nationalities,Baise,Guangxi 533000,China)

机构地区：[1]右江民族医学院临床医学院,广西百色533000 [2]右江民族医学院药学院,广西百色533000 [3]右江民族医学院基础医学院,广西百色533000

出　　处：《中国医学科学院学报》2022年第5期863-867,共5页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(82060540);广西高校中青年教师基础能力提升项目(2022KY0541、2020KY13007)。

摘　　要：普列克底物蛋白同源结构域家族A成员1蛋白(PHLDA1)又称TDAG51,其异常表达与肿瘤的发生、发展和转移密切相关。本文对PHLDA1的基因结构、生物学特性及其在乳腺癌、胃癌、肝癌、黑色素瘤和骨肉瘤等多种恶性肿瘤中的研究进展进行综述,以期更全面综合地了解PHLDA1基因及其对肿瘤诊断治疗的临床意义。Pleckstrin homology like domain family A member 1(PHLDA1)is also known as T-cell death-associated gene 51(TDAG51).Studies have demonstrated that the abnormal expression of PHLDA1 is closely associated with the formation,development,and metastasis of tumors.We summarized the latest research advances in the structure and biological properties of PHLDA1,as well as the roles of PHLDA1 in multiple malignanttumors such as breast cancer,cancer,liver gastric cancer,liver cancer,melanoma,and osteosarcoma,aiming to comprehensively reveal the significance of PHLDA1 in the clinical diagnosis of tumors.

关 键 词：普列克底物蛋白同源结构域家族A成员1蛋白 生物特性 肿瘤 研究进展 

分 类 号：R730.3[医药卫生—肿瘤]