脂质肾毒性机制的研究进展  

Research Progress in Mechanism of Lipid Nephrotoxicity

作　　者：康硕 张瑄[1] KANG Shuo;ZHANG Xuan(Department of Nephrology,Tianjin Children’s Hospital,Tianjin 300204,China)

机构地区：[1]天津市儿童医院综合内科肾脏科,天津300204

出　　处：《中国医学科学院学报》2022年第5期914-918,共5页Acta Academiae Medicinae Sinicae

摘　　要：血脂紊乱可损伤多种器官,肾脏是受累器官之一,脂质诱导产生肾脏损伤的机制包括自噬功能缺陷、氧化应激、内质网应激、炎症反应及表观遗传修饰等,本文就其研究进展做以综述。Dyslipidemia can damage a variety of organs including kidney.The mechanisms of lipid-induced kidney injury include autophagy defects,oxidative stress,endoplasmic reticulum stress,inflammation,and epigenetic modification.This article reviews recent research progress in this field.

关 键 词：脂质肾毒性 异位脂肪沉积 自噬 核苷酸结合寡聚化结构域样受体蛋白3炎症小体 核转录因子ΚB 

分 类 号：R589.2[医药卫生—内分泌] R692[医药卫生—内科学]