油酸包覆的Fe_(3)O_(4)纳米颗粒与DPPG单层膜的相互作用  

Interactions of oleic acid covered Fe_(3)O_(4) nanoparticles with DPPGin monolayers

作　　者：王益祎 朱华泽[1] 刘鑫鑫 WANG Yiyi;ZHU Huaze;LIU Xinxin(College of Science,Xi'an University of Science and Technology,Xi'an 710054,China)

机构地区：[1]西安科技大学理学院,西安710054

出　　处：《功能材料》2022年第10期10146-10156,共11页Journal of Functional Materials

基　　金：国家自然科学基金项目(12004300);陕西省科学技术研究发展计划项目(2016GY-041);西安科技大学博士启动基金项目(2018QDJ021)。

摘　　要：纳米技术的迅速发展增加了纳米颗粒与人类和环境接触的可能,为生物和环境安全带来了风险。纳米颗粒会通过呼吸作用到达肺泡表面,因此探索纳米颗粒与肺表面活性膜中磷脂分子之间的相互作用是十分必要的。利用Langmuir技术测绘了空气-水界面上油酸包覆的Fe_(3)O_(4)磁性纳米颗粒(OA-Fe_(3)O_(4)MNPs)与二棕榈酰磷脂酰甘油(DPPG)分子间相互作用的表面压-平均分子面积(π-A)等温线、表面压-时间(Δπ-t)曲线、压缩-扩张曲线和振荡曲线,同时利用布鲁斯特角显微镜(BAM)实时监测DPPG单层膜的表面形貌特征。研究表明,当界面上DPPG分子数一定时,随着OA-Fe_(3)O_(4)MNPs浓度的增加,π-A等温线向分子面积增大的方向移动;高浓度的OA-Fe_(3)O_(4)MNPs易使DPPG分子与纳米颗粒形成复合体,致使单层膜的表面压显著升高,膜的压缩模量(C_(s)^(-1))显著降低;与纯DPPG单层膜相比,OA-Fe_(3)O_(4)MNPs的存在使得单层膜的表面压在1h内明显下降;OAFe_(3)O_(4)MNPs浓度增加后,DPPG单层膜的扩张曲线存在明显滞后现象;表面压为25mN/m时,DPPG单层膜对5%的正弦应变扰动具有非线性响应特征,OA-Fe_(3)O_(4)MNPs并未改变DPPG单层膜的粘弹性特征以及弛豫过程的时间尺度。BAM图像支持了Langmuir技术的研究结果。The rapid development of nanotechnology has increased the possibility of nanoparticles coming into contact with humans and the environment,bringing risks to biological and environmental safety.Nanoparticles can reach the alveolar surface through respiration,so it is necessary to explore the interaction between nanoparticles and phospholipid molecules in the pulmonary surfactant.The surface pressure-mean molecular area(π-A)isotherms,surface pressure-time(Δπ-t)curves,compression-expansion curves and oscillation curves of oleic acid covered Fe_(3)O_(4) magnetic nanoparticles(OA-Fe_(3)O_(4) MNPs)and phosphatidylglycerole(DPPG)at the air-water interface were measured by Langmuir technique,and the surface morphology characteristics of DPPG monolayers were monitored by Brewster angle microscope(BAM).The results showed that theπ-A isotherms moved to the direction of the increase of the molecular area with the increase of the content of OA-Fe_(3)O_(4) MNPs.OA-Fe_(3)O_(4) MNPs formed complex with DPPG molecules,resulting in a significant increase in the surface pressure and a decrease in the compression modulus(C_(S)^(-1))of the monolayer.Compared with pure DPPG monolayer,the surface pressure of monolayer decreased obviously within one hour due to the existence of OA-Fe_(3)O_(4) MNPs.The expansion curve of DPPG monolayer showed obvious hysteresis with the increase of OA-Fe_(3)O_(4) MNPs.When the surface pressure is 25 mN/m,DPPG monolayers showed nonlinear response to sinusoidal strain disturbance of 5%of molecular area.OA-Fe_(3)O_(4) MNPs did not change the viscoelastic characteristics and the time scale of relaxation process of DPPG monolayers.BAM images supported the above results.

关 键 词：磁性纳米颗粒 表面压 平均分子面积 热力学 流变 粘弹性 

分 类 号：O647[理学—物理化学]