颊脂垫干细胞在骨组织工程中的研究进展  

Research progress of buccal fat pad-derived stem cells in bone tissue engineering

作　　者：杨晓华 何乐人 YANG Xiaohua;HE Leren(Plastic Surgery Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100144)

机构地区：[1]中国医学科学院北京协和医学院整形外科医院,北京市100144

出　　处：《组织工程与重建外科》2022年第5期446-449,453,共5页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：首都卫生发展科研专项项目(编号:2022-2-4042);中国医学科学院临床与转化医学研究专项(编号:2021-I2M-C&T-B-075)。

摘　　要：研究发现颊脂垫中存在具有成骨分化能力的干细胞,可作为骨组织工程的种子细胞诱导新生骨形成。颊脂垫包含两种组分,成熟脂肪组织和基质血管组分,可分别获取去分化脂肪细胞和脂肪间充质干细胞,这两种颊脂垫来源的细胞都具有成骨分化能力。本文对颊脂垫来源的干细胞从成骨能力的发现、与其他干细胞的对比、影响成骨的因素、支架作用,以及临床试验的开展进行综述,总结颊脂垫干细胞的研究应用进展,为骨组织工程种子细胞来源提供参考。Studies have found that there are stem cells with osteogenic differentiation ability in the buccal fat pad,which can be used as seed cells for bone tissue engineering to induce new bone formation.The buccal fat pad contains two components,mature adipose tissue and stromal vascular fraction,from which can separately obtaine dedifferentiated fat cell and adipose stem cells,both of them have osteogenic differentiation ability.In this paper,the buccal fat pad-derived stem cells,from the discovery of osteogenic ability,comparison with other stem cells,factors influencing osteogenesis,the role of scaffolding,to the clinical trials,were all reviewed,and the research and application progress of buccal fat pad-derived stem cells was summarized to provide a reference of the source of seed cells in bone tissue engineering.

关 键 词：颊脂垫 干细胞 骨再生 组织工程 

分 类 号：R318.1[医药卫生—生物医学工程]