骨髓铁染色联合RDW在儿童IDA治疗效果及预后评估中的价值研究  

The value study of bone marrow iron staining combined with RDW in the treatment effect and prognosis evaluation of children’s IDA

作　　者：陆婷婷 梁菠 覃晓虹 LU Tingting;LIANG Bo;QIN Xiaohong(Joint Logistics Support Force 923 Hospital,Nanning,Guangxi 530001,China)

机构地区：[1]联勤保障部队第923医院,广西南宁530001

出　　处：《现代医药卫生》2022年第20期3426-3429,共4页Journal of Modern Medicine & Health

基　　金：广西壮族自治区卫健委青年基金计划课题(Z20200620)。

摘　　要：目的探讨骨髓铁染色联合红细胞分布宽度(RDW)在儿童缺铁性贫血(IDA)中的治疗效果及预后评估中的价值。方法选取2018年7月至2021年1月该院收治的140例IDA患儿作为研究组,经IDA标准化治疗,另选择同期来该院检查的50例健康儿童作为对照组,研究组患儿治疗后与对照组儿童均测定RDW和骨髓铁染色,分析骨髓铁染色联合RDW对IDA预后不良的预测效果。结果研究组患儿平均红细胞体积(MCV)低于对照组,RDW水平高于对照组,骨髓铁染色细胞内铁水平和外铁数均低于对照组,差异均有统计学意义(P<0.05);治疗后6个月,研究组患儿MCV水平较治疗前升高,RDW水平较治疗前降低,骨髓铁染色内铁水平和外铁数较治疗前均升高,差异均有统计学意义(P<0.05)。治疗后6个月,研究组患儿进展8例,稳定21例,改善111例,治疗改善率为79.3%。治疗后随访6个月,研究组患儿预后良好99例,预后不良41例,预后良好率为70.7%。骨髓铁染色联合RDW预测预后不良的敏感度显著高于单独检测,差异有统计学意义(P<0.05),联合预测的受试者工作特征曲线下面积(0.873)显著高于RDW、骨髓铁染色单独预测(0.783、0.754),差异均有统计学意义(P<0.05)。结论骨髓铁染色与RDW联用能够提高儿童IDA预后不良预测的敏感度,具有较好的临床应用价值。Objective To explore the value of bone marrow iron staining combined with red blood cell distribution width(RDW)in the treatment effect and prognosis evaluation of children’s iron-deficiency anemia(ID A).Methods A total of 140 children with IDA admitted from July 2018 to January 2021 were selected as the research group and received IDA standardized treatment,and 50 healthy children who came to this hospital for treatment during the same period were selected as the control group.After treatment,RDW and bone marrow iron staining were measured in both groups,and the predictive effect of bone marrow iron staining combined with RDW on poor prognosis of IDA was analyzed.Results The mean corpuscular volume(MCV)of the children in the research group was lower than that of the control group,and the RDW level of the children in the research group was higher than that of the control group.The level of bone marrow iron staining internal iron and external iron in the research group were both lower than those of the control group,and the differences were statistically significant(P<0.05).After six months of treatment,the MCV of children in the research group were increased,RDW level were decreased,and the level of bone marrow iron staining internal iron and external iron were all increased compared with before treatment,and the differences were statistically significant(P<0.05).After six months of treatment,8 cases of children in the research group were progressed,21 cases were stable,111 cases were improved,and the treatment improvement rate was 79.3%.Followed up for six months after treatment,99 cases of children in the research group had a good prognosis and41 cases had a poor prognosis,with a good prognosis rate of 70.7%.The sensitivity of bone marrow iron staining combined with RDW in predicting poor prognosis was significantly higher than that of the single detection(P<0.05),and the area under the subject working characteristic(ROC)curve of combined prediction(0.873)was significantly higher than that of RDW and bone mar

关 键 词：骨髓铁染色 缺铁性贫血 红细胞分布宽度 治疗 预后 临床价值 儿童 

分 类 号：R441[医药卫生—诊断学]