新型冠状病毒感染对生殖功能的影响  

Investigating the impact of SARS-CoV-2 infection on male/female reproductive function

作　　者：张旖旎 汪萌 朱丽霞 杨骐瑜 聂睿 杨柳[1] 胡娟 席青松 靳镭 Zhang Yini;Wang Meng;Zhu Lixia(Reproductive Medicine Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030;Department of Obstetrics and Gynecology Hospital Affiliated to Fudan University,Shanghai 200011)

机构地区：[1]华中科技大学同济医学院附属同济医院生殖医学中心,武汉430030 [2]复旦大学附属妇产科医院,上海200011

出　　处：《现代妇产科进展》2022年第10期721-725,共5页Progress in Obstetrics and Gynecology

基　　金：湖北省卫生厅科研项目(No:WJ2021M110);中央高校基本科研业务费专项资金(No:2021yjsCXCY095);国家重点研发项目(No:2018YFC1002103)。

摘　　要：目的:探讨新型冠状病毒(SARS-CoV-2)感染对女性卵巢储备和卵巢反应,以及男性精液参数的影响。方法:回顾分析2020年5月至2021年2月于华中科技大学同济医学院附属同济医院生殖医学中心就诊的拟行辅助生殖技术(ART)助孕患者,根据采卵前1周内新型冠状病毒抗体检测结果,分为病例组(新型冠状病毒抗体阳性)和对照组(新型冠状病毒抗体阴性)。对于女性患者,通过倾向性评分匹配均衡两组基线后,比较两组抗穆勒激素(AMH),卵泡刺激素(FSH),窦卵泡数(AFC),促性腺激素剂量和应用时间,以及大卵泡数等。对于男性患者,通过单臂研究观察比较感染前后精液参数,包括精液量、总活力、前向运动力、精子浓度、精子总数以及正常形态精子率等。结果:新型冠状病毒抗体阳性患者共有120例,其中女性70例,男性50例。对于女性患者,匹配基线后,对照组260例,病例组65例,两组的卵巢储备(AMH、FSH、AFC)和卵巢反应(促性腺激素剂量、促性腺激素应用时间和大卵泡数)差异均无统计学意义(P>0.05);对于男性患者,共有26例患者在感染前后均进行精液检测,感染后正常形态精子率相较感染前降低(P=0.001),但其他精液参数无显著差异(P>0.05)。结论:新型冠状病毒感染对女性卵巢储备和卵巢反应无显著影响。新型冠状病毒感染可降低男性精液正常形态精子率,但结果仍在正常范围,对其他重要精液参数无显著影响。Objective:To investigate the impact of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection on female ovarian reserve,ovarian response,and male semen parameters.Methods:This retrospective study analyzed data of patients undergoing assisted reproductive technology(ART)between May 2020 and February 2021 in Reproductive Medicine Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology.According to whether SARS-CoV-2 antibodies test positive within one week before oocyte retrieval,patients were divided into the case group(SARS-CoV-2 antibodies positive)and the control group(SARS-CoV-2 antibodies negative).For females,propensity score matching was performed to balance the characteristics between the groups,and then anti-Müllerian hormone(AMH),follicle stimulation hormone(FSH),antral follicle counting(AFC),gonadotropin dosage,gonadotropin duration,and numbers of large follicles were compared between the groups after matching.For males,a single-arm study was performed to analyze semen parameters,including semen volume,total vitality,progressive motility,semen concentration,the total number of semen,and normal sperm morphology rate,before and after infection.Results:A total of 120 patients were tested as positive for SARS-CoV-2 with 50 males and 70 females.For females,there were 260 patients in the control group and 65 patients in the case group after matching.The ovarian reserve(AMH,FSH,AFC)and ovarian response(gonadotropin dosage,gonadotropin duration,and the number of large follicles)were similar between the groups(P>0.05).For males,26 patients had experienced semen analyses before and after infection.There was a slight decrease in normal form rate(P=0.001),while no significant differences were observed in terms of other semen parameters(P>0.05).Conclusion:SARS-CoV-2 infection has no significant effect on female ovarian reserve and ovarian response.Although the normal form rate is reduced after infection,it is still within the normal range,and the infection shows no

关 键 词：新型冠状病毒 生殖功能 卵巢储备 卵巢反应 精液质量 

分 类 号：R714.8[医药卫生—妇产科学]