脐尿管炎性肌纤维母细胞瘤1例及文献复习  

Urachal inflammatory myofibroblastoma:a case report and literature review

作　　者：陈锦文 汪金荣[2] CHEN Jingwen;WANG Jinrong(Center of Organ Transplantation,Third Xiangya Hospital,Central South University,Changsha 410013,China;Department of Urology,Third Xiangya Hospital,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅三医院器官移植科,湖南长沙410013 [2]中南大学湘雅三医院泌尿外科,湖南长沙410013

出　　处：《邵阳学院学报（自然科学版）》2022年第5期59-64,共6页Journal of Shaoyang University：Natural Science Edition

摘　　要：炎性肌纤维母细胞瘤(inflammatory myofibroblastoma, IMT)是一种少见的良性肿瘤,且侵犯脐尿管非常罕见。目前文献可查到11例脐尿管IMT。脐尿管IMT在临床肿瘤领域常被误诊为是恶性肿瘤,治疗方式会比较激进,而病理结果往往提示不需要扩大根治。该肿瘤具有梭形细胞增殖、明显的炎症浸润和黏液样变性等特征,以前被命名为炎性假瘤或者纤维黏液样假瘤。中南大学湘雅三医院收治1例脐尿管IMT患者,男,24岁,因间歇性尿痛2个月余,脐周疼痛7 d入院,入院前于外院行腹部增强CT考虑脐尿管囊肿并感染,予以抗感染等对症治疗,尿痛症状缓解后予以腹腔镜下脐尿管肿物切除术,病理检查结合免疫组织化学考虑IMT。本病首选治疗一般是手术切除,预后良好,因间变性淋巴瘤激酶(anaplastic lymphoma kinase, ALK)-1阳性预示IMT的肿瘤性质,且其发病机制仍然不清楚,因此,术后常需要长期随访。Inflammatory myofibroblastomas(IMT)is a rare benign tumor and invasion of the urachus is very rare.At present,a total of 11 cases o£urachal IMTs can be found in the literature Database.Urachal IMT is often mistaken for a malignant tumor in clinic oncology.The tumor has spindle cell proliferation,obvious inflammatory infiltration and myxoid degeneration,and is previously named as inflammatory pseudotumor or fibromyxoid pseudotumor.A 24-year-old male patient with urachal IMTs was admitted to Third Xiangya Hospital for intermittent urine pain for more than 2 months and periumbilical pain for 7 days.Symptomatic treatment such as abdominal enhanced CT considering urachal cyst and infection in the other hospital.Laparoscopic urachal tumor resection was performed after the symptoms of urachal pain were relieved.Inflammatory myofibroblastic tumor was considered by pathological examination combined with immunohistochemistry.The first choice of treatment is surgical resection,and the prognosis is good.The positive expression of anaplastic lymphoma kinase(ALK)-1 indicates the tumor characteristic,while,its pathogenesis is still unclear.Consequently,the long-term post-operation follow-up is still necessary.

关 键 词：脐尿管 IMT 腹腔镜 间变性淋巴瘤激酶 

分 类 号：R737.1[医药卫生—肿瘤]