A review: Systematic research approach on toxicity model of liver and kidney in laboratory animals  

作　　者：Abbasali Abbasnezhad Fatemeh Salami Reza Mohebbati 

机构地区：[1]Department of Physiology,Faculty of Medicine,Gonabad University of Medical Sciences,Gonabad,Iran [2]Department of Physiology,Faculty of Medicine,Mashhad University of Medical Sciences,Mashhad,Iran [3]Applied Biomedical Research Center,Mashhad University of Medical Sciences,Mashhad,Iran

出　　处：《Animal Models and Experimental Medicine》2022年第5期436-444,共9页动物模型与实验医学（英文）

摘　　要：Therapeutic experiments are commonly performed on laboratory animals to inves-tigate the possible mechanism(s)of action of toxic agents as well as drugs or sub-stances under consideration.The use of toxins in laboratory animal models,including rats,is intended to cause toxicity.This study aimed to investigate different models of hepatotoxicity and nephrotoxicity in laboratory animals to help researchers advance their research goals.The current narrative review used databases such as Medline,Web of Science,Scopus,and Embase and appropriate keywords until June 2021.Nephrotoxicity and hepatotoxicity models derived from some toxic agents such as cisplatin,acetaminophen,doxorubicin,some anticancer drugs,and other materials through various signaling pathways are investigated.To understand the models of renal or hepatotoxicity in laboratory animals,we have provided a list of toxic agents and their toxicity procedures in this review.

关 键 词：ANIMAL drug toxicity drug-induced abnormality liver dysfunction renal injury 

分 类 号：R965.1[医药卫生—药理学]