毒素-抗毒素系统在细菌生物被膜形成中的作用及调控机制  

The Roles and Regulatory Mechanisms of Toxin-antitoxin System in Bacterial Biofilm Formation

作　　者：侯博[1] 王晨燕[1] 周伦江[1] HOU Bo;WANG Chenyan;ZHOU Lunjiang(Institute of Animal Husbandry and Veterinary Medicine,Fujian Academy of Agricultural Sciences/Fujian Animal Disease Control Technology Development Center,Fuzhou 350013,China)

机构地区：[1]福建省农业科学院畜牧兽医研究所/福建省畜禽疫病防治工程技术研究中心,福州350013

出　　处：《畜牧兽医学报》2022年第10期3326-3334,共9页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金青年项目(31802190);福建省自然科学基金项目(2018J05053);福建省农业科学院青年创新团队项目(CXTD2021014-3);中国农业科学院-福建省人民政府5511协同创新工程项目(XTCXGC2021008)。

摘　　要：毒素-抗毒素(toxin-antitoxin,T-A)系统广泛存在于细菌基因组和质粒中,调控细菌的多种生理活动。细菌生物被膜是细菌适应应激环境(不利环境)而采取的一种生存策略,其具有极强的耐药性及免疫逃逸性,广泛存在于自然界,具有广泛的危害性,严重威胁畜禽和人类的健康。本文对不同类型的T-A系统在细菌生物被膜形成中的作用和分子机制进行综述,旨在为更好地了解和掌握细菌T-A系统在生物被膜形成中的作用和调控关系,为生物被膜的清除和控制奠定基础。Toxin-antitoxin(T-A)system exists widely in bacterial genomes and plasmids,and regulates various physiological activities in bacteria.Bacterial biofilm formation is a survival strategy adopted by bacteria to adapt to stressful environments(adverse environments),which has strong antibiotic resistance and immune escape,and widely exists in nature.Biofilms have extensive harm and seriously threatens to the health of livestock,poultry and human.In this review,the roles and regulatory mechanisms of different types of T-A system in biofilm formation were summarized,aiming to better understand and master the roles and regulatory mechanisms of T-A system in biofilm formation,and lay a foundation for the removal and control of biofilm formation.

关 键 词：生物被膜 毒素-抗毒素系统 细菌 

分 类 号：S852.61[农业科学—基础兽医学]