原发性干燥综合征患者腮腺MRI与唇腺病理分级相关性研究  

Correlation study of parotid MRI and pathological grade of labial gland in diagnosing primary Sjogren’s syndrome

作　　者：顾秀婷 尹笑笑 王苇[1] 李国青 孙其安 张芮 GU Xiu-ting;YIN Xiao-xiao;WANG Wer;LI Guo-qing;SUN Qi-an;ZHANG Rui(Department of Radiology,Medical Imaging Center,Afiliated Hospital of Yangzhou University,Yangzhou 225000,Jiangsu,China;Department of Rheumatology,Afiliated Hospital of Yangzhou University,Yangzhou 225000,Jiangsu,China)

机构地区：[1]扬州大学附属医院医学影像中心影像科,江苏扬州225000 [2]扬州大学附属医院风湿免疫科,江苏扬州225000

出　　处：《生物医学工程与临床》2022年第5期562-566,共5页Biomedical Engineering and Clinical Medicine

基　　金：江苏省科技厅自然科学基金面上项目(BK20201222)。

摘　　要：目的 比较原发性干燥综合征(pSS)腮腺MRI与唇腺活检的诊断效能并探讨MRI分级与唇腺病理分级(LSGB)的相关性。方法 选择怀疑pSS患者92例,其中男性2例,女性90例;年龄25~80岁,平均年龄55.16岁。所有患者均进行腮腺MRI和唇腺活检并进行分级诊断。腮腺MRI分0~4级,≥1级为阳性;唇腺活检分0~4级,≥3级为阳性。绘制受试者工作特性(ROC)曲线,计算曲线下面积,比较两种检查方法的临床诊断效能。用Spearman等级相关性比较两者的相关性。结果 92例患者最终确诊为pSS 63例,其中男性1例,女性62例;年龄25~79岁,平均年龄55.2岁(标准差13.2岁)。腮腺MRI诊断pSS的准确度83.7%,灵敏度87.3%,特异度75.9%;唇腺活检诊断pSS的准确度79.3%,灵敏度76.2%,特异度86.2%。ROC曲线显示腮腺MRI和唇腺活检曲线下面积分别为0.816、0.812;两者在pSS诊断效能比较,差异无统计学意义(P> 0.05)。Spearman等级相关系数分析,两者分级呈正相关,关联系数r为0.736(P <0.01)。结论 腮腺MRI分级与唇腺活检分级具有较高的一致性,两者均可以作为临床诊断pSS的重要手段。Objective To compare the diagnostic value of parotid gland MRI and labial salivary gland biopsy(LSGB) in primary Sjogren’s syndrome(pSS), and detect the correlation between MRI and LSGB grading. Methods A total of 92 patients with suspected pSS were enrolled, which included 2 males and 90 females, aged 25-80 years old with mean age of 55.16 years old. All of them performed parotid gland MRI and LSGB, then underwent grading diagnosis. MRI images of parotid glands were analyzed into grade 0-4, and grade ≥ 1 was positive;LSGB were analyzed into 0-4 grade system, and grade ≥ 3 were positive. The receiver operating characteristic(ROC) curve was drawn to calculate area under curve(AUC). The clinical diag nostic efficacy of 2 methods was compared, and the correlation was analyzed by Speamen grade correlation. Results A total of 63 patients were diagnosed with pSS in 92 cases, which included 1 male and 62 females, aged 25-79 years old with mean age of 55.2 years old(standard deviation ± 13.2 years old). The accuracy of diagnosis, sensitivity, specificity of parotid gland MRI were 83.7 %, 87.3 %, 75.9 %;and LSGB diagnosis were 79.3 %, 76.2 %, 86.2 %. The AUC of parotid gland MRI and LSGB were 0.816 and 0.812. There was no significant difference in diagnostic efficiency of pSS between 2 methods, Spearman rank correlation coefficient analysis showed that there was a positive correlation between 2 grading, r = 0.736(P < 0.01). Conclusion It is demonstrated that MRI grading of parotid gland and LSGB grading showed highly consistent, which could be used as important means for clinical diagnosis of pSS.

关 键 词：原发干燥综合征 腮腺 MRI 唇腺活检 

分 类 号：R445.2[医药卫生—影像医学与核医学] R593.2[医药卫生—诊断学]