限时进食对恶性肿瘤的潜在防治作用  

Potential preventive effect of time-restricted eating on cancer

作　　者：方若欣 严玲[2] 廖正凯[1] Fang Ruoxin;Yan Ling;Liao Zhengkai(Department of Radiation and Medical Oncology,Zhongnan Hospital of Wuhan University,Hubei Key Laboratory of Tumor Biological Behaviors,Hubei Cancer Clinical Study Center,Wuhan 430071 Hubei China;Department of Cardiology,Renmin Hospital of Wuhan University,Hubei Key Laboratory of Metabolic and Chronic Diseases,Wuhan 430060 Hubei China)

机构地区：[1]武汉大学中南医院肿瘤放化疗科,肿瘤生物学行为湖北省重点实验室,湖北省肿瘤医学临床研究中心,武汉430071 [2]武汉大学人民医院心血管内科,代谢与相关慢病湖北省重点实验室,武汉430060

出　　处：《肿瘤代谢与营养电子杂志》2022年第5期555-560,共6页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：国家自然科学基金(81870299)。

摘　　要：间歇性禁食是一种新的饮食干预策略,其可能改善恶性肿瘤治疗的疗效并减少并发症。限时进食是间歇性禁食的一种特殊形式,通常仅限制每天的进食时间窗而不限制热量,除了和其他间歇性禁食手段一样能够控制体重并改善代谢紊乱以外,限时进食还能调节昼夜节律并影响自噬水平,具有潜在的抗衰作用,相关研究已经表明了它预防肿瘤发生以及减缓肿瘤发展的潜力。同时,由于实施方案便利、不良反应轻微,限时进食有着不错的依从性及安全性,有可能成为一种适合肿瘤患者长期实施的辅助治疗方案乃至健康生活方式。本文从改善肥胖和代谢紊乱、调节昼夜节律和自噬水平以及目前与肿瘤相关的研究进展这三个方面阐述了限时进食对恶性肿瘤的潜在作用,旨在为将来的相关研究提供理论依据和探索方向,探讨限时进食作为一种营养干预手段对恶性肿瘤发生的潜在预防作用以及对恶性肿瘤的治疗或辅助治疗作用,以期可以完善对肿瘤患者的营养干预策略,改善患者的生活质量及预后。Intermittent fasting is a novel dietary intervention strategy that has been demonstrated to improve the efficacy of malignancy treatment and reduce complications.Time-restricted eating is a specific form of intermittent fasting.It usually restricts only the daily eating window and not calories.In addition to weight management and improving metabolism like other intermittent fasting methods,time-restricted eating also synchronizes circadian rhythms and affects autophagy levels,which has potential anti-aging effects.Some studies have shown its potential to prevent tumorigenesis and slow tumor progressions.Moreover,due to the unsophisticated implementation and mild side effects,time-restricted eating is safe and well followed.It may become an adjuvant therapy and even a healthy lifestyle suitable for the long-term execution of cancer patients.This paper expounds on the potential impact mechanism of time-restricted eating on the prevention and treatment of cancer from three aspects:improving obesity and metabolic disorders,synchronizing circadian rhythm and up-regulating autophagy,and current research progress related to tumors.The purpose of this review is to provide a theoretical basis and direction for future research to explore the potential preventive effect of time-restricted eating as a nutritional intervention on the occurrence of cancer and the role of treatment or adjuvant therapy for cancer.It is conducive to improve the nutritional strategy for cancer patients and improving the quality of life and prognosis of patients.

关 键 词：限时进食 代谢 昼夜节律 肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]