中年与老年患者全麻诱导置入喉罩时阿芬太尼半数有效量  

Median effective dose of alfentanil for laryngeal mask airway implantation during general anesthesia induction in the middle aged and elderly patients

作　　者：何杰[1] 谢秉樨 张华[1] 杜忠举[1] 王波[1] 夏菊荣[1] HE Jie;XIE Bingxi;ZHANG Hua(Department of Anesthesiology,The Third People's Hospital of Hangzhou,Hangzhou 310009,China)

机构地区：[1]杭州市第三人民医院麻醉科,浙江杭州310009

出　　处：《全科医学临床与教育》2022年第10期891-894,共4页Clinical Education of General Practice

基　　金：浙江省医药卫生科技计划面上项目(2021KY905);杭州市科技局引导项目(20181228Y07);杭州市社会发展科研自主申报项目(20180533B61)。

摘　　要：目的研究全麻诱导靶控输注丙泊酚4.0μg/ml时,中年与老年患者置入喉罩时阿芬太尼的半数有效量(ED_(50))。方法纳入择期行下肢静脉手术及泌尿外科碎石手术的患者40例,按照年龄分为中年组(40~59岁)和老年组(60~79岁),每组20例。全麻诱导以4.0μg/ml靶控输注丙泊酚,采用改良的probit序贯法确定两组置入喉罩时阿芬太尼的ED_(50)。结果靶控输注丙泊酚4.0μg/ml时,中年组阿芬太尼的ED_(50)为13.18μg/kg(95%CI 11.80~19.87);老年组阿芬太尼的ED_(50)为10.13μg/kg(95%CI 9.10~12.19)。中年组阿芬太尼的ED_(50)高于老年组。结论靶控输注丙泊酚4.0μg/ml时,中年组阿芬太尼用于喉罩置入时的ED_(50)为13.18μg/kg,老年组的ED_(50)为10.13μg/kg。Objective To study the median effective dose(ED_(50))of alfentanil during laryngeal mask insertion in middle-aged and elderly patients with target-controlled infusion of propofol 4.0μg/ml induced by general anesthesia.Methods Forty patients undergoing elective lower limb venous surgery and urological lithotripsy were included.They were divided into middle-aged group(40-59 years)and elderly group(60-79 years)according to their age,with 20 patients in each group.General anesthesia was induced with 4.0μg/ml target-controlled infusion of propofol,and a mod-ified probit sequential method was used to determine the ED_(50) of alfentanil for laryngeal mask insertion in both groups.Results The ED_(50) of alfentanil in the middle-aged group was 13.18μg/kg(95%CI 11.80-19.87)and 10.13μg/kg(95%CI 9.10-12.19)when target-controlled infusion of propofol was 4.0μg/ml.The ED_(50) of alfentanil was higher in the middle-aged group than in the older group.Conclusion When target-controlled infusion of propofol was 4.0μg/ml,the ED_(50) of alfentanil for laryngeal mask insertion was 13.18μg/kg in the middle-aged group and 10.13μg/kg in the elderly group.

关 键 词：喉罩 麻醉 阿芬太尼 半数有效量 年龄 

分 类 号：R614.2[医药卫生—麻醉学]