硫酸镁联用硝苯地平治疗妊娠高血压综合征的疗效及相关检测指标的影响  

Effect of magnesium sulfate combined with nifedipine on pregnancy induced hypertension and related indexes

作　　者：王兰君[1] 李梦琪 王慧玲[3] 靳隽[4] WANG Lanjun;LI Mengqi;WANG huiling;JIN Juan(Department of Clinical Laboratory,The First Affiliated Hospital of Xinxiang Medical University,Henan Weihui 9453100 China;Department of Medical Record,The First Affiliated Hospital of Xinxiang Medical University,Henan Weihui 9453100 China;Gynecology Department,The First Affiliated Hospital of Xinxiang Medical University,Henan Weihui 9453100 China;College of Humanities,Xinxiang Medical University,Henan Xinxiang,453003 China.)

机构地区：[1]河南省新乡医学院第一附属医院检验科,河南卫辉453100 [2]河南省新乡医学院第一附属医院病案室,河南卫辉453100 [3]河南省新乡医学院第一附属医院妇科,河南卫辉453100 [4]河南省新乡医学院,河南新乡453003

出　　处：《实验与检验医学》2022年第4期420-424,431,共6页Experimental and Laboratory Medicine

摘　　要：目的考察硫酸镁联用硝苯地平治疗妊娠高血压综合征的疗效及相关检测指标的影响。方法将2019年4月至2021年2月我院82例妊娠期高血压综合征患者随机分为对照组和研究组,各41例。对照组予以硫酸镁注射液,研究组在对照组基础上予以硝苯地平缓释片。记录两组的临床疗效、不良妊娠结局、不良反应、治疗前后的血压(收缩压和舒张压)、肾功能(24 h尿蛋白、24 h尿肌酐)、子宫动脉血流参数[子宫动脉收缩期峰值流速/舒张末期流速(S/D)、阻力指数(Resistance index,RI)、搏动指数(Pulsatility index,PI)、收缩期最大流速(Vmax)和舒张期最小流速(Vmin)]、自我效能(General self-efficacy scale,GSES)、Mishel疾病不确定感量表(Mishel's uncertainty in illness scale,MUIS)、凝血功能[凝血酶原时间(Prothrombin time,PT)、凝血酶时间(Thrombin time,TT)、活化部分凝血活酶时间(Activated partial thromboplastin time,APTT)、纤维蛋白原(Fibrinogen,FIB)]和内分泌指标[促卵泡激素(Follicle-stimulating hormone,FSH)、催乳素(Prolactin,PRL)、促黄体酮生成激素(Luteinizing hormone,LH)]。结果研究组临床总有效率高于对照组(P<0.05)。治疗后,与对照组比,研究组血压、24 h尿蛋白、24 h尿肌酐、S/D、RI、PI、PT、TT、APTT、FSH、PRL、LH降低(均P<0.05),Vmax、Vmin、GSES、FIB升高(均P<0.05),与对照组比,研究组不良妊娠结局发生较少(P<0.05)。两组患者均未出现明显的不良反应。结论硫酸镁联用硝苯地平治疗妊娠期高血压综合征的临床效果较好,改善血压、肾功能、子宫动脉血流参数、自我效能、疾病不确定感、凝血功能、内分泌及母婴结局。Objective To investigate the effect of magnesium sulfate combined with nifedipine in the treatment of pregnancy-induced hypertension syndrome on detection indicators and pregnancy outcome.Methods A total of 82 patients with pregnancy-induced hypertension in our hospital from April 2019 to February 2021 were selected and randomly divided into the control group and the observation group,41 casesper group.The control group was given magnesium sulfate injection,and the observation group was given nifedipine sustained-release tablets based on the control group.The clinical efficacy,adverse pregnancy outcome and adverse effect of 2 groups were recorded and compared.The blood pressure(systolic and diastolic blood pressure),renal function(24 h urine protein,24 h urine creatinine),uterine artery blood flow parameters[uterine artery peak systolic flow rate/end diastolic flow rate(S/D),Resistance index(RI),(Pulsatility index,PI),maximum systolic flow rate(Vmax)and minimum diastolic flow rate(Vmin)],(General self-efficacy scale,GSES),Mishel's uncertainty in illness scale(MUIS),blood coagulation function[Prothrombin time(PT),Thrombin time(TT),Activated partial thromboplastin time(APTT)and Fibrinogen(FIB)]and endocrine indicators[Follicle-stimulating hormone(FSH),Prolactin(PRL),Luteinizing hormone(LH)]of 2 groups were recorded and compared.Results The total clinical effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,compared with the control group,the blood pressure,diastolic blood pressure,24h urine protein,24h urine creatinine,S/D、RI、PI、PT、TT、APTT、FSH、PRL and LHhad decreased(P<0.05),Vmax,Vmin,GSESand FIB had increased in the observation group(P<0.05).Compared with the control group,the observation group had fewer adverse pregnancy outcomes(P>0.05).There were no obvious adverse reactions in 2 groups.Conclusion The clinical effect of magnesium sulfate combined with nifedipine in the treatment of pregnancy-induced hypertension syndrome is good,which can improv

关 键 词：硫酸镁 硝苯地平 妊娠高血压综合征 血压 肾功能 

分 类 号：R714.246[医药卫生—妇产科学]