核糖核酸 N^(6)-甲基腺嘌呤修饰在动脉粥样硬化中的研究进展  

Research progress of RNA N^(6)-methyladenosine modification in atherosclerosis

作　　者：蓝翊宁 张艳[1] 揭春晓 李胜昆 程道宾[1] Lan Yining;Zhang Yan;Jie Chunxiao;Li Shengkun;Cheng Daobin(Department of Neurology,the First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530021,China)

机构地区：[1]广西医科大学第一附属医院神经内科,南宁530021

出　　处：《中国脑血管病杂志》2022年第10期705-711,共7页Chinese Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金(82060248);广西壮族自治区研究生教育创新计划项目(YCSW2022212)。

摘　　要：N^(6)-甲基腺嘌呤(m^(6)A)修饰是指腺嘌呤N^(6)位发生甲基化,是近年来发现的真核生物核糖核酸(RNA)中最丰富、最常见、最保守的内部修饰。最新研究表明,RNA m^(6)A修饰与动脉粥样硬化(AS)的发生发展密切相关,m^(6)A修饰及其相关因子可能通过调控炎性反应、脂质积累等途径参与AS,但其具体调控机制尚未明确。该文拟对RNA m^(6)A甲基化修饰进行综述,重点阐述RNA m^(6)A修饰及其相关因子在AS中的作用和潜在的调控机制。N^(6)-methyladenosine(m^(6)A)modification refers to the methylation of adenineN 6,which is the richest,most abundant and conservative internal modification in eukaryotic RNA discovered in recent years.The latest study found that RNA m^(6)A modification is closely related to the development of atherosclerosis(AS).The m^(6)A modification and its associated factors may participate in AS through the regulation of inflammation,lipid accumulation,etc.However,its specific regulatory mechanism is still unclear.Therefore,this review briefly introduced RNA m^(6)A methylation modification,focusing on the role of RNA m^(6)A modification in AS and potential regulatory mechanisms.

关 键 词：动脉粥样硬化 N-6甲基腺嘌呤 综述 

分 类 号：R543.5[医药卫生—心血管疾病]