益气养阴消癥通络中药治疗早期糖尿病肾病的临床研究  

Clinical Study on the Treatment of Early Diabetic Nephropathy With Traditional Chinese Medicine for Nourishing Qi,Nourishing Yin,Eliminating Symptoms and Dredging Collaterals

作　　者：杜新国 于新 DU Xinguo;YU Xin(Department of Pharmacy,Rushan Hospital of Traditional Chinese Medicine,Rushan Shandong 264500,China)

机构地区：[1]乳山市中医院药剂科,山东乳山264500

出　　处：《中国卫生标准管理》2022年第17期158-162,共5页China Health Standard Management

摘　　要：目的探讨益气养阴消癥通络中药治疗早期糖尿病肾病的临床疗效。方法选取2019年3月—2021年4月在乳山市中医院就诊的84例早期糖尿病肾病患者,将患者随机分为常规西医治疗的对照组(42例)和益气养阴消癥通络中药治疗的观察组(42例)。比较两组临床疗效,对比两组干预前后的血糖水平、肾功能、血脂水平,统计两组不良反应发生率。结果观察组临床总有效率高于对照组,差异有统计学意义(P<0.05);干预后观察组糖化血红蛋白为(6.73±1.20)%、空腹血糖为(5.61±1.54)mmol/L、餐后2 h血糖为(6.35±1.12)mmol/L,均低于对照组的(7.92±1.18)%、(7.36±1.48)mmol/L、(7.72±1.09)mmol/L,血清肌酐为(63.29±4.11)μmol/L、血尿素氮胆固醇为(4.21±0.53)mmol/L,均低于对照组的(68.44±4.02)μmol/L、(4.97±0.62)mmol/L,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论早期糖尿病肾病应用益气养阴消癥通络中药治疗,能促使患者的血糖血脂水平得以控制,肾功能得到改善,且药物不良反应少,值得推广使用。Objective To explore the clinical effect of nourishing Qi,nourishing Yin,eliminating symptoms and dredging collaterals traditional Chinese medicine in the treatment of early diabetic nephropathy.Methods A total of 84 patients with early diabetic nephropathy who were treated in Rushan Hospital of Traditional Chinese Medicine from March 2019 to April 2021 were selected,the patients were randomly divided into the control group(42 cases)treated with conventional western medicine and the observation group(42 cases)treated with traditional Chinese medicine for nourishing Qi,nourishing Yin,eliminating symptoms and dredging collaterals.The clinical efficacy of the two groups was compared,and the blood glucose levels,renal function,and blood lipid levels were compared between the two groups before and after the intervention,and the incidence of adverse reactions in the two groups was calculated.Results The total clinical effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After intervention,the glycated hemoglobin of the observation group was(6.73±1.20)%,the fasting blood glucose was(5.61±1.54)mmol/L,and the 2 h postprandial blood glucose was(6.35±1.12)mmol/L,which were all lower than those of the control group(7.92±1.18)%,(7.36±1.48)mmol/L,(7.72±1.09)mmol/L,serum creatinine was(63.29±4.11)μmol/L,blood urea nitrogen cholesterol was(4.21±0.53)mmol/L,both were lower than(68.44±4.02)μmol/L and(4.97±0.62)mmol/L of the control group,the differences were statistically significant(P<0.05);the incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Early diabetic nephropathy is treated with the traditional Chinese medicine of nourishing Qi,nourishing Yin,eliminating symptoms and dredging collaterals,which can promote the control of blood glucose and blood lipid levels in patients,improve renal function,and have few adverse drug r

关 键 词：糖尿病肾病 益气养阴消癥通络药 疗效 血糖 肾功能 血脂 不良反应 

分 类 号：R242[医药卫生—中医临床基础]