间质性肺病合并肺部感染的病原学特征分析  

Etiological analysis of interstitial lung disease complicated with pulmonary infection

作　　者：赵静[1] 杨婷[2] 杜小琴[3] 张俣[1] 王丽萍 努阿力亚·库尔班 ZHAO Jing;YANG Ting;DU Xiao-qin;ZHANG Yu;WANG Li-ping;Nualiya·kuerban(The Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;The Fifth Affiliated Hospital of Xinjiang Medical University)

机构地区：[1]新疆医科大学第五附属医院呼吸与危重症医学科,新疆乌鲁木齐830011 [2]新疆医科大学第五附属医院临床药学科 [3]新疆医科大学第五附属医院全科医学

出　　处：《中国病原生物学杂志》2022年第9期1103-1105,1110,共4页Journal of Pathogen Biology

基　　金：新疆维吾尔自治区卫生健康青年医学科技人才专项科研项目(No.WJWY-202145);中国药学会科技开发中心科普项目(No.CMEI2022KPYJ00258)。

摘　　要：目的通过对间质性肺病合并肺部感染的临床资料进行分析,探讨感染的临床特点和病原分布,为该病早期识别和诊治提供依据。方法选取间质性肺病合并肺部感染患者临床资料作为感染组,并选取同期间质性肺病未发生感染的患者作为对照组。对患者的一般资料、临床特点和实验室指标进行记录和对比。将间质性肺病合并肺部感染患者的样本进行培养,并进行病原学鉴定。结果两组患者一般资料中年龄、病程和BMI数据差异有统计学意义(P>0.05)。临床特点中发热、咳嗽、咳痰、气促、胸闷和肺部干湿啰音数据差异有统计学意义(P<0.05),而口干和肌肉痛数据差异无统计学意义(P>0.05)。实验室检测指标中WBC、ALB、CRP和lgG数据差异有统计学意义(P<0.05),补体C3和补体C4数据差异无统计学意义(P>0.05)。28例患者中21例单一感染,7例混合感染。本次研究中检出12株病毒和26株病原菌。病毒检出情况为:6株巨细胞病毒,4株EB病毒和2株单纯疱疹病毒。病原菌检出情况为:5株肺炎克雷伯菌,5株白色假丝酵母菌,3株铜绿假单胞菌,3株肺炎链球菌,3株曲霉菌,2株鲍曼不动杆菌,1株金黄色葡萄球菌,1株嗜麦芽假单胞菌,1株洋葱伯克霍尔德菌,1株产吲哚黄杆菌和1株隐球菌。结论肺部感染是间质性肺病的常见并发症,病原体具有多样性,其中白色假丝酵母菌和肺炎克雷伯菌检出率较高。当患者满足合并肺部感染的临床特点和实验室指标时,应及时进行病原学检测,并进行有效的治疗。Objective By analyzing the clinical data of interstitial lung disease(ILD)with pulmonary infection,this paper discusses the clinical characteristics and pathogen distribution of interstitial lung disease with pulmonary infection,so as to provide basis for early identification and diagnosis and treatment of the disease.Methods The clinical data of patients with interstitial lung disease complicated with pulmonary infection were selected as the infection group,and the patients without interstitial lung disease infection in the same period were selected as the control group.The general information,clinical characteristics and laboratory indicators of patients were recorded and compared.The samples of patients with ILD and pulmonary infection were cultured and identified.Results There was no significant difference in age,course of disease and BMI between the two groups(P>0.05).Among the clinical characteristics,the data of fever,cough,expectoration,shortness of breath,chest tightness and lung dry and wet rales were statistically significant(P<0.05),while the data of thirst and muscle pain were not statistically significant(P>0.05).The difference of WBC,ALB,CRP and LGG data in laboratory test indicators was statistically significant(P<0.05),while the difference of complement C3 and complement C4 data was not statistically significant(P>0.05).Among the 28 patients,21 were single infection and 7 were mixed infection.12 viruses and 26 pathogens were detected in this study.The detection of the virus was:6 strains of cytomegalovirus,4 strains of EB virus and 2 strains of herpes simplex virus.The pathogenic bacteria detected were:5 strains of Klebsiella pneumoniae,5 strains of Candida albicans,3 strains of Pseudomonas aeruginosa,3 strains of Streptococcus pneumoniae,3 strains of Aspergillus,2 strains of Acinetobacter baumannii,1 strain of S.aureus,1 strain of P.maltophilia,1 strain of Burkholderia cepacia,1 strain of Flavobacterium indole and 1 strain of Cryptococcus.Conclusion Pulmonary infection is a common complication o

关 键 词：间质性肺病 肺部感染 病原学 

分 类 号：R378[医药卫生—病原生物学]