伊维菌素抗寄生虫病和寄生虫感染的作用研究进展  

Research progress on the effect of ivermectin against parasitic diseases and parasitic infections

作　　者：舒磊 刘星卓 吕芳丽 SHU Lei;LIUXing-zhou;LV Fang-li(Artemisinin Research Center,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Department of Parasitology,Zhongshan School of Medicine,Sun Yat-sen University;Department of Clinical Laboratory,The Seventh Affiliated Hospital,Sun Yat-sen University;Key Laboratory of Tropical Disease of Ministry of Education,Sun Yat-sen University)

机构地区：[1]广州中医药大学青蒿研究中心,广东广州510405 [2]中山大学中山医学院寄生虫学教研室 [3]中山大学附属第七医院检验科 [4]中山大学热带病防治研究教育部重点实验室

出　　处：《中国病原生物学杂志》2022年第8期972-977,共6页Journal of Pathogen Biology

基　　金：国家自然科学基金面上项目(No.81971955,81873218);广东省自然科学基金面上项目(No.2019A1515011667,2021A1515012115);2021年广东省研究生教育创新计划项目(No.2021SFKC003);中山大学本科教学质量与教学改革工程项目(中大教务[2021]93号,中大教务[2022]91号)。

摘　　要：伊维菌素可治疗盘尾丝虫病和淋巴丝虫病,防治土源性蠕虫(包括似蚓蛔线虫、毛首鞭形线虫、钩口属线虫和粪类圆线虫)和体外寄生虫(包括疥螨和头虱)感染,控制传播疟疾的按蚊并杀灭其体内的疟原虫,并且对曼氏血吸虫的尾蚴、毛蚴和中间宿主淡水螺等有一定的杀灭作用。本文对伊维菌素抗上述寄生虫病和寄生虫感染的作用研究进展进行综述,以期为相关研究者提供参考。Ivermectin can treat onchocerciasis and lymphatic filariasis,prevent and treat the infection of soil-borne helminths(including Ascaris lumbricoides,Trichuris trichura,Ancylostoma spp.,and Strongyloides stercoralis)and ectoparasites(including Sarcoptes scabies and Pediculus humanus capitis),control Anopheles mosquitoes those transmit malaria and kill Plasmodium parasites inside Anopheles mosquitoes,kill cercariae and miracidia of Schistosoma mansoni,and its intermediate host(freshwater snails).This paper reviews the research progress of ivermectin against the above-mentioned parasitic diseases and parasitic infections,to provide reference for relevant researchers.

关 键 词：伊维菌素 土源性蠕虫 按蚊 曼氏血吸虫 体外寄生虫 综述 

分 类 号：R38[医药卫生—医学寄生虫学]