冠状动脉造影血流储备分数对不同性别心肌缺血诊断价值的影响  

Evaluation of diagnostic value of coronary angiography-based fractional flow reserve in different gender

作　　者：杨威 李慧萍 杜耀 郭权 晏娟娟 高传玉[1,2] YANG Wei;LI Hui-ping;DU Yao;GUO Quan;YAN Juan-juan;GAO Chuan-yu(Department of Cardiology,Fuwai Central China Cardiovascular Hospital.Heart Center of Henan Provincial People's Hospital,Zhengzhou 450003,China)

机构地区：[1]阜外华中心血管病医院,郑州450003 [2]河南省人民医院心脏中心,郑州450003

出　　处：《医药论坛杂志》2022年第16期13-16,共4页Journal of Medical Forum

基　　金：河南省医学科技攻关计划项目(201701019)。

摘　　要：目的 评价冠状动脉造影血流储备分数(caFFR)与导丝血流储备分数(FFR)对不同性别冠心病患者缺血诊断价值的影响。方法 回顾性分析2021年11月至2022年2月在阜外华中心血管病医院行冠脉造影,发现至少有1支主要冠状动脉直径狭窄50%~90%(造影视觉评估),且同时行经导丝FFR检查和caFFR检查的64例冠心病患者(血管数64支)。分析caFFR在女性组(n=34)与男性组(n=30)患者中与FFR的相关性、一致性,以FFR≤0.8作为心肌缺血金标准,比较caFFR在两组间的诊断价值。结果 女性组FFR与caFFR的相关性良好(r=0.951,P<0.01);男性组FFR与caFFR的相关性良好(r=0.964,P<0.01)caFFR在女性组和男性组的诊断准确性95.1%比96.4%、敏感性87.5%比85.7%、特异性88.9%比85.7%、阳性预测值87.5%比88.9%、阴性预测值88.9%比85.7%,差异均无统计学意义(P>0.01)。caFFR诊断受试者工作特征曲线下面积(AUC)女性组为0.951(95%CI:0.818~0.996),男性组为0.964(95%CI:0.824~0.999)。两组相比差异无统计学意义(Z=0.293,95%CI:-0.0733~0.0991,P>0.01)。结论 冠状动脉造影caFFR与导丝FFR对冠心病患者均具有良好的相关性、一致性,性别对caFFR值没有影响。Objective To evaluate diagnostic value of coronary angiography-based fractional flow reserve(caFFR) versus wire-based fractional flow reserve(FFR) in patients with coronary heart disease. Methods A total of 64 patients(64 vessels) who underwent a pressure wire-based FFR measurement from Nov. 2021 to Feb. 2022 in Fuwai central China cardiovascular hospital were enrolled. Coronary angiography images and simultaneous aortic pressure were blind processed for caFFR. The ischemia diagnostic value of caFFR was evaluated by wire-based FFR with cut-off value of≤0.80. The correlation and consistency of caFFR and wire-based FFR were analyzed and compared between female(n=34) and male(n=30) groups. Results The caFFR had a good correlation and consistency with wire-based FFR in both female group(r=0.951, P<0.01)and male group(r=0.964,P<0.01). In female group versus male group, diagnostic accuracy of caFFR was 95.1% versus 96.4%, diagnostic sensitivity of caFFR was 87.5% versus 85.7%, diagnostic specificity of caFFR was 88.9%versus 85.7%, all P>0.05. The area under the receiver operating characteristic curve of caFFR had no significant difference between female and male patients(0.951 vs.0.964, Z=0.293 95% CI:-0.0733-0.0991, P>0.05). Conclusion The caFFR has a good diagnostic correlation and consistency with wire-based FFR in both gender. The diagnostic value of caFFR in female patients is similar to that of male patients with coronary heart disease.

关 键 词：冠心病 血流储备分数 性别 

分 类 号：R541[医药卫生—心血管疾病]