李孔定教授治疗慢性阻塞性肺疾病用药经验挖掘  

Prof.LI Kong-ding’s Experience in the Treatment of Chronic Obstructive Pulmonary Disease

作　　者：陈锦云 王春荣 沈其霖[2] CHEN Jin-yun;WANG Chun-rong;SHEN Qi-lin(School of Basic Medicine,Chengdu University of Chinese Medicine,Chengdu 610000;Department of Pulmonary Disease,Mianyang Hospital of Traditional Chinese Medicine,Sichuan 621000)

机构地区：[1]成都中医药大学基础医学院,成都610000 [2]四川省绵阳市中医医院肺病科,四川621000

出　　处：《中国中西医结合杂志》2022年第9期1058-1062,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：四川省中医药管理局——李孔定中医药流派工作室(No.川中医药办发[2019]26号)。

摘　　要：目的探究李孔定教授运用中医药治疗慢性阻塞性肺疾病(COPD)组方的用药规律。方法收集整理李孔定教授的门诊病历,提取其中治疗COPD且记录完整的处方,录入Excel表格建立数据库,运用IBM SPSS Statistics 23进行频数、系统聚类分析;运用IBM SPSS Modeler 18.0进行关联规则分析。结果共筛选处方76首,涉及中药146味,频次较高的药物有黄芩、甘草、南沙参、赤芍、黄精等,药性以寒、温为主,药味以苦、甘、辛为主。归经以肺经为主,涉及脾、胃、肝、肾等多个脏腑,并得到二阶和三阶关联规则药物组合,通过系统聚类分析方法得到聚类5方。结论李孔定教授治疗COPD用药具有治肺活血、温清并施、培土生金、扶正与祛邪兼顾四大特点。Objective To study the prescription and medication rules of Prof.LI Kongding’s treatment of chronic obstructive pulmonary disease(COPD)with Chinese medicine.Methods The outpatient medical records written by Prof.LI were collected and sorted out.The prescriptions for the treatment of COPD with complete records were extracted.The Excel was entered to build database.Frequency and systematic cluster analysis were performed using IBM SPSS Statistics 23.Association rule analysis was performed using IBM SPSS Modeler 18.0.Results A total of 76 prescriptions were selected,involving 146 kinds of Chinese herbs.The most frequently used medicines were Scutelaria Baicalensis,liquorice root,Radix Adenophorae,red peony root,Polygonatum Kingianum,and so on.The medicinal properties were mainly cold and warm,and medicinal tastes were mainly bitter,sweet,and pungent.The main organs belong to Fei,involving Pi,Wei,Gan,Shen,and so on.Combinations of drugs with second-order and third-order association rules were obtained,and clustering 5prescriptions were also obtained by systematic clustering analysis method.Conclusion Prof.LI’s treatment of COPD had the four characteristics:treating Fei and activating blood circulation,warming and clearing,cultivating soil and generating gold,strengthening the body vitality and eliminating evil.

关 键 词：慢性阻塞性肺疾病 数据挖掘 用药规律 

分 类 号：R249[医药卫生—中医临床基础] R259[医药卫生—中医学]