补体受体及共抑制分子VSIG4的研究进展  

Progress in complement receptor and co-inhibitory molecule VSIG4

作　　者：陈孝杰 李世朋 孙丽莹[2] 朱志军[1] Chen Xiaojie;Li Shipeng;Sun Liying;Zhu Zhijun(Liver Transplantation Center,National Clinical Research Center for Digestive Diseases,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;Department of Critical Liver Disease,Liver Research Center,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院普外科肝脏移植中心,国家消化系统疾病临床医学研究中心,北京100050 [2]首都医科大学附属北京友谊医院重症肝病科,北京100050

出　　处：《中华微生物学和免疫学杂志》2022年第9期749-752,共4页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(81970562)。

摘　　要：巨噬细胞表达的共刺激分子VSIG4(V set and Ig domain-containing 4)是一种B7家族相关蛋白,可作为T细胞活化的第二信号,调节T细胞的功能状态。同时,VSIG4也可作为补体受体,发挥识别病原体、调节补体旁路途径及抑制炎症反应的作用,在维持免疫耐受方面发挥着重要作用。本文回顾总结了VSIG4的表达及其在机体免疫中的作用。V set and Ig domain containing 4(VSIG4),a co-inhibitory molecule expressed by macrophages,is a B7 family-related protein.It can serve as the second signal of T cell activation and regulate the function of T cells.It has been found that VSIG4 is essential in maintaining immune tolerance.Moreover,VSIG4 can also act as a complement receptor,playing a role in recognizing pathogens,regulating the complement alternative pathway and inhibiting inflammatory response.This review summarized the expression of VSIG4 and its role in the immune system.

关 键 词：VSIG4 巨噬细胞 固有免疫 适应性免疫 

分 类 号：R392[医药卫生—免疫学]