肠吉泰颗粒治疗老年大肠癌患者术后肝郁脾虚型腹泻的疗效评价  

Effect evaluation of Changjitai granule on liver stagnation and spleen deficiency diarrhea in elderly patients with colorectal cancer after operation

作　　者：程雪桦 贾明磊 洪慰麟[3] 童佳凤 任翱翔 丛军[5] 蔡淦[5] 张征宇 韩力[1] Cheng Xuehua;Jia Minglei;Hong Weilin;Tong Jiafeng;Ren Aoxiang;Cong Jun;Cai Gan;Zhang Zhengyu;Han Li(Department of Internal Medicine of Traditional Chinese Medicine,Huadong Hospital Affiliated to Fudan University,Shanghai,200040,P.R.China;Department of Gastroenterology,Huadong Hospital Affiliated to Fudan University,Shanghai,200040,P.R.China;Department of Cardiovascular Medicine,Huadong Hospital Affiliated to Fudan University,Shanghai,200040,P.R.China;Department of Acupuncture,Central Hospital of Jing an District,Shanghai,200040,P.R.China;Department of Spleen and Stomach Diseases,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200021,P.R.China;Department of Pharmacy,Huadong Hospital Affiliated to Fudan University,Shanghai,200040,P.R.China)

机构地区：[1]复旦大学附属华东医院中医内科,上海200040 [2]复旦大学附属华东医院消化内科,上海200040 [3]复旦大学附属华东医院心血管内科,上海200040 [4]上海市静安区中心医院针灸科,上海200040 [5]上海中医药大学附属曙光医院脾胃病科,上海200021 [6]复旦大学附属华东医院药剂科,上海200040

出　　处：《老年医学与保健》2022年第5期1058-1062,共5页Geriatrics & Health Care

基　　金：上海市进一步加快中医药事业发展三年行动计划综合医院中西医结合专项(ZY(2018-2020)-FWTX-3016);上海市第二批中医专科(专病)联盟建设项目[沪卫中管(2021)13号];第六批全国老中医药专家学术经验继承工作项目[国中医药人教发(2017)29号]。

摘　　要：目的观察肠吉泰颗粒治疗老年大肠癌术后腹泻患者的疗效。方法选取2018年3月—2021年3月华东医院中医科病房和门诊收治的大肠癌术后肝郁脾虚型腹泻的患者72例,采用随机数字法分为观察组和对照组,每组36例。观察组采用口服肠吉泰颗粒治疗,对照组采用口服谷参治疗,2组疗程均为4周,观察患者治疗前后MSKCC肠道功能积分、肝郁脾虚中医证候评分、Bristol粪便性状评分,评价临床疗效。结果(1)观察组总有效率94.1%,对照组总有效率71.4%,观察组优于对照组(P<0.05);(2)组内比较,治疗后2组的中医证候积分、Bristol粪便性状评分均显著下降,而观察组的MSKCC肠道功能积分上升(P<0.05);(3)组间对比,治疗后观察组的MSKCC肠道功能积分、Bristol粪便性状评分以及中医证候积分均高于对照组(P<0.05);(4)2组在治疗期间均未出现严重不良反应及肝肾功能异常。结论肠吉泰能安全有效改善老年大肠癌术后肝郁脾虚型腹泻患者的临床症状和中医证候。Objective To observe the curative effect of Changjitai granule in elderly patients with diarrhea after colorectal cancer surgery.Methods From March 2018 to March 2021,72 patients with liver stagnation and spleen deficiency diarrhea after colorectal cancer surgery admitted to the Ward and Outpatient Department of Internal Medicine of Traditional Chinese Medicine(TCM) of Huadong Hospital were selected and divided into observation group and control group by random number method,with 36 cases in each group.The observation group was treated with oral Changjitai granules,while the control group was treated with oral Gushen.The course of treatment in both groups was 4 weeks.MSKCC intestinal function score,TCM syndrome score of liver stagnation and spleen deficiency,Bristol stool trait score before and after treatment were observed to evaluate the clinical efficacy.Results(1)The total effective rate of the observation group was 94.1%,which was obviously higher than that of the control group(71.4%)(P<0.05).(2) Compared within the group,the TCM syndrome score and Bristol stool trait score in the two groups decreased significantly after treatment,while the MSKCC intestinal function score in the observation group increased(P<0.05).(3) After treatment,the MSKCC intestinal function score,Bristol stool trait score and TCM syndrome score of the observation group were higher than those of the control group(P <0.05).(4) No serious adverse reaction and abnormal liver and kidney function occurred in both groups during treatment.Conclusion Changjitai granule can safely and effectively improve the clinical symptoms and TCM syndromes of elderly patients with liver stagnation and spleen deficiency diarrhea after colorectal cancer surgery.

关 键 词：老年 大肠癌 术后腹泻 肝郁脾虚证 肠吉泰 

分 类 号：R273[医药卫生—中西医结合]