盐酸利托君联合低分子量肝素钠治疗先兆流产患者的临床疗效  

Clinical curative effect of ritodrine hydrochloride combined with low-molecular weight heparin sodium in treatment of patients with threatened abortion

作　　者：刘海燕 杜二球 LIU Hai-Yan;DU Er-Qiu(Department of Gynecology and Obstetrics,Taizhou Central Hospital,Affiliated Hospital of Taizhou College,Taizhou,Zhejiang 318000,China)

机构地区：[1]台州市中心医院(台州学院附属医院)妇产科,浙江台州318000

出　　处：《中国妇幼保健》2022年第19期3590-3593,共4页Maternal and Child Health Care of China

基　　金：浙江省医药卫生科技计划项目(2020RC145)。

摘　　要：目的分析盐酸利托君联合低分子量肝素钠治疗先兆流产患者的临床疗效。方法选取2019年1月—2021年1月台州市中心医院收治的年龄24~35岁的108例先兆流产患者,随机分为联合组(54例)和对照组(54例)。两组患者均给予常规治疗,对照组在此基础上给予低分子量肝素钠治疗,联合组在对照组基础上给予盐酸利托君治疗,两组均治疗7 d。比较治疗前、治疗7 d后性激素水平、子宫动脉血流水平、临床症状及不良反应发生率,统计两组治疗总有效率。结果治疗后,两组患者血清孕酮(P)、雌二醇(E_(2))、β-人绒毛膜促性腺激素(β-hCG)水平比较差异均有统计学意义(均P<0.05),两组患者阻力指数(RI)、搏动指数(PI)及收缩期峰值流速/舒张期流速(S/D)比值比较差异均有统计学意义(均P<0.05)。联合组腹痛消失时间、腰痛消失时间、宫缩消失时间及阴道出血停止时间分别为(2.85±0.80)d、(3.05±0.75)d、(6.45±1.94)h及(3.20±1.17)d;对照组腹痛消失时间、腰痛消失时间、宫缩消失时间及阴道出血停止时间分别为(4.71±0.85)d、(4.56±0.95)d、(9.94±2.40)h及(4.95±1.35)d。联合组患者腹痛消失时间、腰痛消失时间、宫缩消失时间及阴道出血停止时间均显著短于对照组,差异均有统计学意义(t=11.710,P<0.05;t=9.168,P<0.05;t=8.310,P<0.05;t=7.199,P<0.05)。联合组患者不良反应总发生率(12.96%)均显著低于对照组(29.63%),差异有统计学意义(χ^(2)=4.475,P<0.05)。联合组治疗总有效率(96.30%)显著高于对照组(77.78%),差异有统计学意义(χ^(2)=8.207,P<0.05)。结论盐酸利托君联合低分子量肝素钠能够提高先兆流产患者性激素水平,改善患者临床症状,降低子宫动脉血流水平和不良反应发生率,提高治疗有效率。Objective To analyze the clinical curative effect of ritodrine hydrochloride combined with low-molecular weight heparin sodium in treatment of patients with threatened abortion.Methods From January 2019 to January 2021,108 patients with threatened abortion(aged 24-35 years old)treated in Taizhou Central Hospital were selected and randomly divided into combined group and control group,54 cases in each group.The patients in the two groups were treated with routine therapy,the patients in control group were treated with low-molecular weight heparin sodium,the patients in combined group were treated with low-molecular weight heparin sodium combined with ritodrine hydrochloride,the patients in the two groups were treated for 7 days.The levels of sex hormones,uterine artery blood flow,clinical manifestations,and incidence rates of adverse reactions in the two groups were compared between before treatment and at 7 days after treatment,the total effective rates in the two groups were compared.Results After treatment,there were statistically significant differences in the levels of serum progesterone(P),estradiol(E_(2)),andβ-human chorionic gonadotropin(β-hCG)between the two groups(P<0.05),there were statistically significant differences in resistance index(RI),pulsatility index(PI),and the ratio of peak systolic velocity to end diastolic velocity(S/D)between the two groups(P<0.05).The disappearance time of abdominal pain,the disappearance time of backache,the disappearance time of uterine contraction,and the stop time of vaginal hemorrhage in combined group were(2.85±0.80)days,(3.05±0.75)days,(6.45±1.94)hours,and(3.20±1.17)days,respectively;the disappearance time of abdominal pain,the disappearance time of backache,the disappearance time of uterine contraction,and the stop time of vaginal hemorrhage in control group were(4.71±0.85)days,(4.56±0.95)days,(9.94±2.40)hours,and(4.95±1.35)days,respectively.The disappearance time of abdominal pain,the disappearance time of backache,the disappearance time of uterine con

关 键 词：盐酸利托君 低分子量肝素钠 先兆流产 性激素 子宫动脉血流 

分 类 号：R714.21[医药卫生—妇产科学]