小剂量胰岛素结合电解质补充治疗儿童糖尿病酮症酸中毒的临床效果分析  

Clinical Effect Analysis of Low-dose Insulin Combined with Electrolyte Supplementation in the Treatment of Children with Diabetic Ketoacidosis

作　　者：陈尔东 黄文丹 郑庆锋 卢蔚薇 CHEN Erdong;HUANG Wendan;ZHENG Qingfeng;LU Weiwei(Department of Pediatrics,Zhengxing Hospital,Zhangzhou,Fujian Province,363000 China;Department of Pediatrics,No.909 Hospital,Joint Logistics Support Force of the Chinese People's Liberation Army,Zhangzhou,Fujian Province,363000 China)

机构地区：[1]福建省漳州正兴医院儿科,福建漳州363000 [2]中国人民解放军联勤保障部队第九〇九医院儿科,福建漳州363000

出　　处：《糖尿病新世界》2022年第17期13-16,共4页Diabetes New World Magazine

摘　　要：目的 探讨对儿童糖尿病酮症酸中毒患者采用小剂量胰岛素+电解质补充方法完成治疗后获得临床效果。方法 选取福建省漳州正兴医院2017年7月—2022年4月收治的60例糖尿病酮症酸中毒患儿,随机分为常规组(采用电解质补充方法完成治疗)和研究组(在常规组基础上,联合小剂量胰岛素治疗),各30例。比较两组患儿治疗总有效率、pH值恢复时间、血糖达标时间、尿酮体消除时间、尿素氮、肌酐、二氧化碳结合力(CO_(2)CP)、血钾、血糖及血钠。结果 研究组治疗总有效率(96.67%)较常规组(73.33%)明显提高,差异有统计学意义(P<0.05);研究组pH值恢复时间、血糖达标时间、尿酮体消除时间较常规组明显缩短,差异有统计学意义(P<0.05);治疗前,两组尿素氮、肌酐、CO_(2)CP比较,差异无统计学意义(P>0.05);治疗后,研究组尿素氮、肌酐较常规组明显降低,CO_(2)CP较常规组明显提高,差异有统计学意义(P<0.05);治疗前,两组血钾、血糖及血钠比较,差异无统计学意义(P>0.05);治疗后,研究组血钾较常规组明显提升,血糖及血钠较常规组明显降低,差异有统计学意义(P<0.05)。结论 应用小剂量胰岛素+电解质补充方法,疗效显著,可促进糖尿病酮症酸中毒患儿预后良好。Objective To investigate the clinical effect of low-dose insulin + electrolyte supplementation in children with diabetic ketoacidosis.Methods A total of 60 children with diabetic ketoacidosis who were admitted in the Zhengxing Hospital, Zhangzhou, Fujian Province from July 2017 to April 2022 were selected for treatment research,and were randomly divided into routine group(complete the treatment with electrolyte supplementation) and study group(on the basis of routine group, combined with low-dose insulin therapy), 30 cases in each. The total effective rate of treatment, pH recovery time, blood glucose reaching time, urine ketone elimination time, blood urea nitrogen,creatinine, carbon dioxide binding capacity(COCP), serum potassium, blood glucose and serum sodium were compared between the two groups.Results The total effective rate of treatment in the study group(96.67%) was significantly higher than that in the routine group(73.33%), and the difference was statistically significant(P<0.05). Compared with the routine group, the pH recovery time, blood glucose reaching time, and urine ketone elimination time in the study group were significantly shorter than those in the routine group, and the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in blood urea nitrogen, creatinine and COCP in the study group compared with the routine group(P>0.05). After treatment, blood urea nitrogen and creatinine in the study group were significantly lower than those in the routine group, and COCP was significantly higher than those in the routine group, the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in serum potassium, blood glucose and serum sodium in the study group compared with the routine group(P>0.05). After treatment, the serum potassium in the study group was significantly higher than that in the routine group, and the blood glucose and serum sodium were significantly lower than tho

关 键 词：小剂量胰岛素 电解质补充 儿童糖尿病酮症酸中毒 治疗效果 

分 类 号：R725.8[医药卫生—儿科]