自噬途径在急性肾损伤中的作用及靶向治疗策略研究进展  

Research progress on the role of autophagy pathway in acute renal injury and targeted treatment strategies

作　　者：李侃[1] 肖啸 周森 高丽[3] 陈启明[4] 姜倩 康智鸿 刘天喜[1] Li Kan;Xiao Xiao;Zhou Sen;Li Gao;Chen Qiming;Jiang Qian;Kang Zhihong;Liu Tianxi(Department of Nephrology,First Hospital of Lanzhou University,Lanzhou 730000,China;First Clinical Medical College of Lanzhou University,Lanzhou 730000,China;Department of Gynaecology,First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Intensive Care Unit,First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一医院肾病科,兰州730000 [2]兰州大学第一临床医学院,兰州730000 [3]兰州大学第一医院妇科,兰州730000 [4]兰州大学第一医院重症医学科,兰州730000

出　　处：《中国综合临床》2022年第5期466-470,共5页Clinical Medicine of China

基　　金：甘肃省自然科学基金(20JR5RA350,21JR7RA388);甘肃省高等学校创新能力提升项目(2020B-007);兰州大学第一临床医学院卓越计划项目(20210060168);兰州大学第一临床医学院大学生创新创业行动计划项目(20210060168)。

摘　　要：自噬是用于降解细胞质组分的高度保守的细胞内分解代谢过程,近年来,因其在急慢性肾脏病发病机制及靶向治疗方面的重要性而备受关注。在生理和病理条件下,自噬在维持肾脏稳态中的作用至关重要,利用各种肾脏细胞组织特异性的条件性自噬相关基因敲除的研究逐步揭示了自噬在肾脏疾病中扮演的角色。最近的研究发现,自噬缺陷在肾脏不同病理状态下可能发挥关键作用,激活自噬在肾小球和肾小管间质中均表现出细胞保护功能,表明自噬的上调可能成为一种有潜力的治疗策略。然而,也有相反的证据表明自噬可能是有害的,这对研发针对上调自噬的治疗策略提出了巨大的挑战。Autophagy is a highly conserved intracellular catabolic process used to degrade cytoplasmic components.In recent years,it has attracted much attention because of its importance in the pathogenesis and targeted therapy of acute and chronic kidney disease.Autophagy plays an important role in maintaining renal homeostasis under physiological and pathological conditions.The study of conditional autophagy related gene knockout specific to various renal cells has gradually revealed the role of autophagy in renal diseases.Recent studies have found that autophagy deficiency may play a key role in different pathological states of the kidney.Activated autophagy shows cytoprotective function in both glomerulus and renal tubulointerstitium,suggesting that the up regulation of autophagy may become a potential therapeutic strategy.However,there is also contrary evidence that autophagy may be harmful,which poses a great challenge to the development of therapeutic strategies for up-regulated autophagy.

关 键 词：自噬途径 自噬相关基因 急性肾损伤 雷帕霉素靶蛋白 靶向治疗 

分 类 号：R692[医药卫生—泌尿科学]