炎症因子在小儿急性肠炎中的表达及临床意义分析  

Analysis on Expression and Clinical Significance of Inflammatory Factors in Children with Acute Enteritis

作　　者：周洪华[1] Zhou Hong-hua(Department of Pediatrics,Karamay Central Hospital of Xinjiang,Karamay 834000,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]新疆克拉玛依市中心医院儿科,新疆克拉玛依834000

出　　处：《中国社区医师》2022年第27期102-104,共3页Chinese Community Doctors

摘　　要：目的:探讨炎症因子在小儿急性肠炎中的表达及临床意义。方法:选择新疆克拉玛依市中心医院2020年1月-2021年1月收治的260例急性肠炎患儿作为观察组,同时选择260例健康儿童作为对照组。对比两组患儿炎症因子[白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]水平,观察组患儿感染性和非感染性患儿的炎症因子水平。结果:观察组患儿IL-10、IL-6、TNF-α水平高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患儿IL-10、IL-6、TNF-α水平低于治疗前,差异有统计学意义(P<0.05)。观察组感染性患儿的IL-10、IL-6、TNF-α水平高于非感染性患儿,差异有统计学意义(P<0.05)。结论:临床诊疗时可以根据炎症因子水平判断小儿急性肠炎的类型和病情进展程度,炎症因子水平越高表明病情越重。Objective:To explore the expression and clinical significance of inflammatory factors in children with acute enteritis.Methods:Two hundred and sixty children with acute enteritis admitted to Karamay Central Hospital of Xinjiang from January 2020 to January 2021 were selected as the observation group,and 260 healthy children during the same period were selected as the control group.The differences of inflammatory factors[interleukin-10(IL-10),interleukin-6(IL-6),tumor necrosis factorα(TNF-α)]levels between the two groups were compared,and the levels of inflammatory factors of infectious children and non infectious children in the observation group were compared.Results:The levels of IL-10,IL-6 and TNF-αin the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of IL-10,IL-6 and TNFαin the observation group were lower than those before treatment,and the difference was statistically significant(P<0.05).The levels of IL-10,IL-6,and TNF-αin infectious children was higher than those in non infectious children in the observation group,and the difference was statistically significant(P<0.05).Conclusion:In clinical diagnosis and treatment,the type and progression of acute enteritis in children can be judged according to the level of inflammatory factors.The higher the level of inflammatory factors,the more serious the disease is.

关 键 词：炎症因子 小儿急性肠炎 白细胞介素-10、白细胞介素-6、肿瘤坏死因子-α 

分 类 号：R725.7[医药卫生—儿科]