分泌蛋白Metrnl在不同疾病中作用的研究进展  

Research progress on the role of secretory protein Metrnl in different diseases

作　　者：张蓝月 张学东[1] ZHANG Lan-yue;ZHANG Xue-dong(Department of Ophthalmology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400000,China)

机构地区：[1]重庆医科大学附属第一医院眼科,重庆400000

出　　处：《基础医学与临床》2022年第11期1767-1770,共4页Basic and Clinical Medicine

基　　金：国家自然科学基金(818704093)。

摘　　要：镍纹样蛋白(Metrnl)是一种与神经营养因子Meteorin同源的新的细胞因子,也是一种分泌蛋白,其基因及产物表现为低组织特异性,在体内广泛表达。该蛋白可类似神经营养因子、脂肪因子、炎性因子及肌肉因子,在机体神经发育、免疫炎性反应、代谢等多方面发挥作用。Metrnl is a new cytokine with homologous orignination from neurotrophic factor Meteorin.Meanwhile,as a secreting protein,its gene and products show low tissue specificity and is widely expressed in different tissues of host.Similar to neurotrophic factor,adipocytokines,inflammatory factor and muscle factor,the protein plays a role in neural development,immune inflammatory response and metabolism and so on.

关 键 词：镍纹样蛋白(Metrnl) 神经营养因子 能量代谢 胰岛素抵抗 免疫调节 

分 类 号：R335[医药卫生—人体生理学] R392.6[医药卫生—基础医学]