地塞米松注射治疗亚急性甲状腺炎的疗效观察  

Efficacy observation of dexamethasone injection in the treatment of subacute thyroiditis

作　　者：张星宇 ZHANG Xing-yu(Central Hospital Affiliated to Shenyang Medical College,Shenyang 110024,China)

机构地区：[1]沈阳医学院附属中心医院内分泌科,110024

出　　处：《中国实用医药》2022年第21期150-152,共3页China Practical Medicine

摘　　要：目的分析地塞米松注射治疗亚急性甲状腺炎患者的临床疗效。方法80例亚急性甲状腺炎患者,依据随机数字表法分为观察组与对照组,各40例。对照组采用泼尼松口服治疗,观察组采用地塞米松注射治疗。比较两组甲状腺体积恢复正常时间、颈部疼痛消失时间、体温恢复正常时间,治疗前后甲状腺功能指标、红细胞沉降率(血沉),治疗效果及不良反应发生情况。结果观察组甲状腺体积恢复正常时间(8.45±2.56)d、颈部疼痛消失时间(6.13±1.50)d、体温恢复正常时间(4.21±1.55)d均短于对照组的(11.55±3.15)、(9.54±2.45)、(6.54±2.12)d,差异有统计学意义(P<0.05)。治疗后,两组游离三碘甲状腺原氨酸、游离四碘甲状腺原氨酸、促甲状腺激素、血沉水平均优于本组治疗前,且观察组优于对照组,差异均有统计学意义(P<0.05)。观察组治疗总有效率97.50%高于对照组的75.00%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论地塞米松注射治疗亚急性甲状腺炎临床效果确切,可缓解患者临床症状和改善甲状腺功能,有效降低血沉,安全性高,值得推广。Objective To analyze the clinical efficacy of dexamethasone injection in the treatment of subacute thyroiditis.Methods A total of 80 patients with subacute thyroiditis were randomly divided into observation group and control group according to the digital table,with 40 cases in each group.The control group was treated with oral prednisone,and the observation group was treated with dexamethasone injection.Both groups were compared in terms of recovery time of thyroid volume,disappearance time of neck pain,recovery time of body temperature,thyroid function indexes and erythrocyte sedimentation rate before and after treatment,therapeutic effect and occurrence of adverse reactions.Results In the observation group,the recovery time of thyroid volume was(8.45±2.56)d,the disappearance time of neck pain was(6.13±1.50)d,and the recovery time of body temperature was(4.21±1.55)d,which were shorter than(11.55±3.15),(9.54±2.45)and(6.54±2.12)d in the control group,and the differences were all statistically significant(P<0.05).After treatment,the levels of free triiodothyronine,free tetraiodothyronine,thyroid stimulating hormone and erythrocyte sedimentation rate in the two groups were better than those before treatment in this group,and the observation group was better than the control group.The differences were all statistically significant(P<0.05).The total effective rate 97.50%of the observation group was higher than 75.00%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Dexamethasone injection has definite clinical effect in the treatment of subacute thyroiditis,and can relieve clinical symptoms and improve thyroid function of patients,effectively reduce erythrocyte sedimentation rate with high safety,which is worthy of promotion.

关 键 词：地塞米松 亚急性甲状腺炎 临床效果 

分 类 号：R581.4[医药卫生—内分泌]