秦汉时期六本方书散结方剂组方用药特点探析  

Composition Rule of Stagnation-Eliminating Formulas in Six Medical Classics in Qin and Han Dynasties

作　　者：张逸雯 邢颖 江丽杰[1] ZHANG Yi-wen;XING Ying;JIANG Li-jie(Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700;Post-doctoral Research Station,China Academy of Chinese Medical Sciences,Beijing 100700;Institute of Information on Tra-ditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700)

机构地区：[1]中国中医科学院中医基础理论研究所,北京100700 [2]中国中医科学院博士后流动站,北京100700 [3]中国中医科学院中医药信息研究所,北京100700

出　　处：《世界中西医结合杂志》2022年第9期1704-1708,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：国家重点研发计划(2019YFC1708501);中国中医科学院中央级公益性科研院所专项资金资助项目(YZ-202123);佛山市科技创新项目(2020001005585)。

摘　　要：目的应用数据挖掘方法,分析和总结秦汉时期存世文献中具有散结功效的方剂组方用药特点,为临床治疗提供参考。方法检索《中华医典》收录的宋以前医著散结方剂信息,录入中医古今医案云平台及Geghi复杂网络分析系统,采用软件集成的数据挖掘方法,分析方剂的组方用药规律。结果共纳入方剂83首,涉及中药226味。使用药物频次及药对频次结果显示,使用频率超过20%的中药包括大黄、甘草、肉桂、干姜、人参、黄芩六味,频次均在18次及以上,常用2味药对当归-肉桂、大黄-黄芩、生姜-半夏、茯苓-白术等,支持度0.10,置信度超过0.50。不同的结证用药具有显著差异,热结证中大黄出现频次最高,痰结证中肉桂、生姜、半夏药物使用频次居前3位,血结证用药以大黄、当归、川芎三药分列前3位,结气病的用药以人参为主。结论秦汉时期散结组方思路是化痰、活血通络、清热/温通、补虚理气。核心药对为生姜-半夏化痰、当归-川芎活血、大黄-黄芩清热、茯苓-白术健脾。核心处方为小半夏汤、四物汤。Objective To analyze and summarize the composition rule of formulas with the efficacy of eliminating stagnation in the medical classics in Qin and Han dynasties by data mining and to serve as a reference for clinical treatment.Methods The information of stagnation-eliminating formulas in medical writings before Song Dynasty included in the Chinese Medical Classics was retrieved and input into the Ancient and Modern Medical Record Cloud Platform and Geghi Complex Network Analysis System,and data mining was performed based on software integration to analyze the composition rule of the formulas.Results A total of 83 prescriptions were included,involving 226 Chinese medicinals.The medicinals with use frequency>20%included Rhei Radix et Rhizoma,Glycyrrhizae Radix et Rhizoma,Cinnamomi Cortex,Zingiberis Rhizoma,Ginseng Radix et Rhizoma,and Scutellariae Radix,all of which were used 18 times or more.The commonly used pairs were Angelicae Sinensis Radix-Cinnamomi Cortex,Rhei Radix et Rhizoma-Scutellariae Radix,Zingiberis Rhizoma Recens-Pinelliae Rhizoma,and Porias-Atractylodis Macrocephalae Rhizoma,with support of 0.10 and the confidence of>0.50.Medicinals for different syndromes were different.The use frequency of Rhei Radix et Rhizoma was the highest for heat accumulation syndrome.Cinnamomi Cortex,Zingiberis Rhizoma Recens,and Pinelliae Rhizoma topped the medicinals for phlegm accumulation syndrome.The use frequency of Rhei Radix et Rhizoma,Angelicae Sinensis Radix,and Chuanxiong Rhizoma was the highest for blood stagnation syndrome.Ginseng Radix et Rhizoma was mainly used for qi stagnation syndrome.Conclusion The method for eliminating stagnation in the Qin and Han dynasties was to resolve phlegm,activate blood,clear heat/warm and dredge,and tonify deficiency and regulate qi.The core medicinal pairs were Zingiberis Rhizoma Recens-Pinelliae Rhizoma for resolving phlegm,Angelicae Sinensis Radix-Chuanxiong Rhizoma for activating blood,Rhei Radix et Rhizoma-Scutellariae Radix for clearing heat,and Porias-Atractylodis Macroc

关 键 词：结证 散结 古代 方剂 

分 类 号：R2-03[医药卫生—中医学]