血浆miR-1、miR-133a表达与急性心肌梗死患者中医症状改善的相关性  

Correlation of Plasma miR-1 and miR-133a Levels with Alleviation of TCM Symptoms in Patients with Acute Myocardial Infarction

作　　者：宋秀荣[1] 赵瑞平[2] 唐宇 卢耀军[1] 王飞[1] 李永明[1] SONG Xiu-rong;ZHAO Rui-ping;TANG Yu;LU Yao-jun;WANG Fei;LI Yong-ming(Department of Cardiology,Baotou Central Hospital,Baotou Inner Mongolia 014040;Department of Physical Examina-tion,Baotou Central Hospital,Baotou Inner Mongolia 014040)

机构地区：[1]包头市中心医院心内科,内蒙古包头014040 [2]包头市中心医院体检科,内蒙古包头014040

出　　处：《世界中西医结合杂志》2022年第9期1792-1796,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：内蒙古自治区自然科学项目(2017MX038);包头市医药卫生科技计划项目(wjwk12020002)。

摘　　要：目的通过观察血浆miR-1、miR-133a水平与患者中医临床症状改善情况的关系,以期促进急性心肌梗死患者良性预后。方法回顾性分析2020年1月—2021年2月期间包头市中心医院收治的100例急性心肌梗死患者的临床资料,根据患者中医临床症状改善情况进行分组,将临床治愈、显效、有效均纳入中医症状改善良好组(77例),治疗无效患者纳入中医症状改善无效组(23例),所有患者均为中医治疗方法(西洋参、三七各10 g),疗程为7 d。观察比较两组患者实验室相关指标(外周血中miR-1、miR-133a相对表达量),分析血浆miR-1、miR-133a表达与急性心肌梗死患者中医症状改善的相关性。结果100例急性心肌梗死患者经中医治疗后,临床治愈20例,显效25例,有效32例,无效23例;无效组miR-1、miR-133a、中医证候积分均高于良好组,差异有统计学意义(P<0.05);将急性心肌梗死患者中医症状改善情况作为因变量,将差异有统计学意义的变量作为自变量并赋值,经多元回归分析得到方程:Y=-0.350+0.335X(miR-1)+0.238X(miR-133a),结果显示急性心肌梗死患者血浆miR-1、miR-133a水平表达可能是中医症状改善情况的影响因素,差异有统计学意义(P<0.05);经双变量Pearson直线相关性检验结果显示,急性心肌梗死患者血浆miR-1、miR-133a与中医证候积分均呈正相关(r>0,P<0.05)。结论血浆miR-1、miR-133a表达与急性心肌梗死患者中医症状改善情况密切相关,血浆中miR-1、miR-133a过表达是影响患者中医症状改善情况的关键,临床可通过针对性干预手段调控急性心肌梗死患者血浆中miR-1、miR-133a的表达,旨在显著改善患者临床症状,促进良性预后。Objective To observe the relationship of plasma miR-1 and miR-133a levels with the alleviation of TCM symptoms,so as to promote the benign prognosis of patients with acute myocardial infarction.Methods The clinical data of 100 patients with acute myocardial infarction admitted to Baotou Central Hospital from January 2020 to February 2021 were retrospectively analyzed.The patients were assigned into a TCM symptom alleviated group(77 patients,including cured,remarkedly effective,and effective)and a TCM symptom non-alleviated group(12 patients).All the patients were treated with TCM therapy(10 g Panacis Quinquefolii Radix and 10 g Notoginseng Radix et Rhizoma)for 7 days.The laboratory-related indicators(relative expression of miR-1 and miR-133a in peripheral blood)were compared between the two groups,and the correlation of plasma miR-1 and miR-133a levels with the alleviation of TCM symptoms in patients with acute myocardial infarction was analyzed.Results The TCM therapy cured 20 patients and was remarkedly effective for 25 patients,effective for 32 patients,and ineffective for 23 patients.The TCM symptom non-alleviated group has higher miR-1 level,miR-133a level,and TCM symptom score than the TCM symptom alleviated group(P<0.05).The multivariate regression with the alleviation of TCM symptoms as the dependent variable and the significantly different variables as the independent variables gave the equation of Y=0.350+0.335X(miR-1)+0.238X(miR-133a),which indicated that plasma miR-1 and miR-133a levels may be factors influencing the alleviation of TCM symptoms(P<0.05).The results of bivariate Pearson straight-line correlation test showed that plasma miR-1 and miR-133a levels were positively correlated with the TCM symptom score(r>0,P<0.05).Conclusion Plasma miR-1 and miR-133a levels are associated with TCM symptom alleviation in patients with acute myocardial infarction.Plasma miR-1 and miR-133a overexpression is the key to the alleviation of TCM symptoms in patients.In clinical practice,the expression of miR-1 and m

关 键 词：急性心肌梗死 中医症状 MIR-1 miR-133a 相关性 

分 类 号：R542.2[医药卫生—心血管疾病]