温阳活血法治疗缓慢性心律失常临床疗效和安全性的系统评价及Meta分析  

Systematic review and Meta-analysis of the Clinical Efficacy and Safety of Warming Yang and Activating Blood in the Treatment of Bradyarrhythmias

作　　者：王旭杰 张菀桐 张雪雪 王妙然 张蕊[1,3] 张继伟[1] 顾继昱[1,3] 倪恬 唐威 吴宇飞 谭晓宁 李秋艳 翁维良[1] WANG Xu-jie;ZHANG Wan-tong;ZHANG Xue-xue;WANG Miao-ran;ZHANG Rui;ZHANG Ji-wei;GU Ji-yu;NI Tian;TANG Wei;WU Yu-fei;TAN Xiao-ning;LI Qiu-yan;WENG Wei-liang(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091;Graduate School of China Academy of Chinese Medical Sciences,Beijing 100700;Beijing University of Chinese Medicine,Beijing 100029)

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]中国中医科学院研究生院,北京100700 [3]北京中医药大学,北京100029

出　　处：《世界中西医结合杂志》2022年第8期1503-1509,共7页World Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金项目(82004352);中央级公益性科研院所基本科研业务费专项资金资助(ZZ15-XY-PT-08);国家中医药管理局第三届国医大师传承工作室及全国名中医传承工作室建设项目:翁维良全国名中医传承工作室。

摘　　要：目的系统评价温阳活血法治疗缓慢性心律失常的临床疗效及安全性。方法计算机检索CNKI、VIP、WanFang Data、PubMed等数据库,纳入相关随机对照试验后进行评价,采用Revman 5.3软件提取、分析数据。结果最终共纳入13篇文献,共计1171例受试者。结果显示温阳活血法治疗缓慢性心律失常的临床疗效优于对照组(OR=4.33,95%CI=[2.97,6.31],P<0.001)。以静息心率为评价指标的文献共纳入2篇,温阳活血组提高静息心率的临床效果优于对照组(MD=3.33,95%CI=[1.38,5.28],Z=3.34,P<0.001)。以24 h最低心率为评价指标的文献共纳入7篇,温阳活血组提高24 h最低心率的临床效果优于对照组(MD=7.09,95%CI=[2.99,11.18],Z=3.39,P<0.001)。以24 h平均心率为评价指标的文献共纳入9篇,温阳活血组提高24 h平均心率的临床效果优于对照组(MD=5.83,95%CI=[3.67,8.00],Z=5.28,P<0.001)。以24 h最高心率为评价指标的文献共纳入6篇,温阳活血组提高24 h最高心率的临床效果优于对照组(MD=7.70,95%CI=[7.02,8.38],Z=22.16,P<0.001)。共7篇文献报道了使用温阳活血法治疗的不良反应,各组不良反应发生率低,均为轻症,未影响治疗。结论温阳活血法临床治疗缓慢性心律失常安全有效,值得临床推广。Objective To systematically evaluate the clinical efficacy and safety of warming yang and activating blood the treatment of bradyarrhythmias.Methods Databases such as CNKI,VIP,Wanfang Data,and PubMed were searched,and relevant randomized controlled trials were included for evaluation.Revman 5.3 was used to extract and analyze the data.Results Thirteen articles were included,with a total of 1171 subjects.The clinical efficacy of warming yang and activating blood group in the treatment of bradyarrhythmias was better than that of the control group(OR=4.33,95%CI=[2.97,6.31],P<0.001).Two articles using resting heart rateas evaluation indicator were included,andthe clinical efficacy of warming yang and activating blood group in improving resting heart rate was better than that of the control group(MD=3.33,95%CI=[1.38,5.28],Z=3.34,P<0.001).There were 7,9,and 6 articles included using the 24 h minimum heart rate,24 h average heart rate,and 24 h maximum heart rate as evaluation indicators,respectively.The clinical efficacies of warming yang and activating blood group in increasing the 24 h minimum heart rate,24 h average heart rate,and 24 h maximum heart rate were better than those of the control group(MD=7.09,95%CI=[2.99,11.18],Z=3.39,P<0.001;MD=5.83,95%CI=[3.67,8.00],Z=5.28,P<0.001;MD=7.70,95%CI=[7.02,8.38],Z=22.16,P<0.001).Seven articles reported the adverse reactions of warming yang and activating blood,but the incidence of adverse reactions in each group was low,all of which were mild and did not affect the treatment.Conclusion The clinical treatment of bradyarrhythmias with warming yang and activating blood was safe and effective,and was worthy of clinical promotion.

关 键 词：缓慢性心律失常 温阳活血 系统评价 META分析 

分 类 号：R541.7[医药卫生—心血管疾病]