基于络病理论自拟中药-足浴二联法治疗糖尿病周围神经病变的疗效观察  

Therapeutic Effect of Self-made Chinese Medicine-Foot Bath Combination Therapy Based on Collateral Disease Theory on Diabetic Peripheral Neuropathy

作　　者：张彬 杨英俏 万亮 张迪 薛薇 ZHANG Bin;YANG Ying-qiao;WAN Liang;ZHANG Di;XUE Wei(Internal MedicineⅠ,Jinzhou Hospital of Traditional Chinese Medicine,Jinzhou Liaoning 121000)

机构地区：[1]锦州市中医医院内一科,辽宁锦州121000

出　　处：《世界中西医结合杂志》2022年第8期1605-1608,1614,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：辽宁省科学技术计划项目省自然基金资助计划(2019-229)。

摘　　要：目的观察基于络病理论自拟中药-足浴二联法治疗糖尿病周围神经病变(Diabetic peripheral neuropathy,DPN)的疗效观察。方法选取2018年2月—2020年10月期间于锦州市中医医院就诊的DPN患者114例,按随机数字表法分为对照组和研究组,每组各57例。对照组予以西医常规治疗,研究组在此基础上加自拟中药-足浴二联方治疗。连续治疗3疗程后,观察比较两组患者临床疗效,治疗前后的中医证候(肢体疼痛、麻木、发凉、感觉异常、倦怠乏力、畏寒喜暖)评分、多伦多临床评分系统(Toronto clinical scoring system,TCSS)评分、血液流变学指标(血浆黏度、全血还原黏度、低切全血黏度、高切全血黏度)、足部感觉阈值评分及神经传导速度(正中、腓总神经的运动、感觉神经传导速度)及不良反应情况。结果治疗后研究组总有效率87.27%(48/55)高于对照组70.91%(39/55),差异有统计学意义(P<0.05)。治疗后两组患者中医证候、TCSS评分均低于治疗前,差异有统计学意义(P<0.05);且研究组中医证候、TCSS评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血液流变学各项指标均低于治疗前,差异有统计学意义(P<0.05);且研究组均低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者足部压力、震动感觉阈值评分均高于治疗前,差异有统计学意义(P<0.05);且研究组均高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者正中、腓总神经的运动、感觉神经传导速度均高于治疗前,差异有统计学意义(P<0.05);且研究组均高于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应比较,差异无统计学意义(P>0.05)。结论基于络病理论自拟中药-足浴二联法治疗DPN疗效理想,可有效减轻其临床症状,改善血液流动性、足部感觉阈值及神经传导速度,值得临床推广。Objective To observe the clinical effect of self-made Chinese medicine-foot bath combination therapy based on the collateral disease theory on diabetic peripheral neuropathy(DPN).Methods A total of 114 DPN patients who were treated in Jinzhou Hospital of Traditional Chinese Medicine from February 2018 to October 2020 were selected and divided into the control group(n=57)and the study group(n=57)according to a random number table.The control group was given conventional western medicine,and the study group received self-made Chinese medicine-foot bath combination therapy on the basis of the control group.After 3 courses of treatment,the clinical effect of the two groups was compared.Additionally,the score of traditional Chinese medicine(TCM)syndromes(limb pain,numbness,and coldness,abnormal sensation,tiredness,fear of cold and desire for warm),Toronto clinical scoring system(TCSS)score,hemorheological indexes(plasma viscosity,whole blood reduced viscosity,low-shear whole blood viscosity,high-shear whole blood viscosity),sensory threshold score of foot and nerve conduction velocity(the motor and sensory conduction velocities of median and common peroneal nerve),and adverse reactions were compared between the two groups before and after treatment.Results In both groups,2 cases dropped out and 55 cases were finally included.After treatment,the total effective rate of the study group[87.27%(48/55)]was higher than[70.91%(39/55)]of the control group(P<0.05).The TCM syndrome score,TCSS score and hemorheological indexes of both groups after treatment were lower than those before treatment(P<0.05),with the study group having more significant reduction than the control group(P<0.05).Moreover,the scores of foot pressure and vibration sensory threshold,the motor and sensory conduction velocities of the median and common peroneal nerves in the two groups were higher than those before treatment(P<0.05),with the study group having more significant increase than the control group(P<0.05).There was no remarkable difference in adve

关 键 词：糖尿病周围神经病变 络病理论 中药-足浴二联法 

分 类 号：R587.2[医药卫生—内分泌]