自拟益气舒胸活血方对气虚血瘀型冠脉支架内再狭窄患者血管内皮功能及血液流变学影响  

Effect of Self-made Yiqi Shuxiong Huoxue Recipe on Vascular Endothelial Function and Hemorheology in Patients with Coronary In-Stent Restenosis of Qi Deficiency and Blood Stasis Type

作　　者：张存峰 闫志如 杨慧芳[1] 张成 ZHANG Cun-feng;YAN Zhi-ru;YANG Hui-fang;ZHANG Cheng(Department of Cardiology,Chinese Medicine Hospital of Puyang,Puyang Henan 457001;Department of Cardiology,Puyang People′s Hospital,Puyang Henan 457099)

机构地区：[1]濮阳市中医院心血管内科,河南濮阳457001 [2]濮阳市人民医院心内科,河南濮阳457099

出　　处：《世界中西医结合杂志》2022年第8期1619-1623,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：2018年度河南省医学科技攻关计划项目(2018020813)。

摘　　要：目的观察自拟益气舒胸活血方对气虚血瘀型冠脉支架内再狭窄患者的血管内皮功能及血液流变学影响。方法选取2018年4月—2020年8月期间于濮阳市中医院就诊的气虚血瘀型冠脉支架内再狭窄患者116例,按照随机数字表法分为对照组和治疗组,每组各58例。对照组给予西医常规治疗,治疗组在对照组基础上给予自拟益气舒胸活血方治疗。治疗4个月后,观察比较两组患者治疗前后心电图疗效、血液流变学指标[血浆黏度(Plasma Viscosity,PV)、低切全血黏度(Low-Whole Blood Viscosity,L-WBV)、中切全血黏度(Medium-Whole Blood Viscosity,M-WBV)、高切全血黏度(High-Whole Blood Viscosity,H-WBV)]、血脂四项水平[总胆固醇(Total Cholesterol,TC)、甘油三酯(Triglyceride,TG)、高密度脂蛋白胆固醇(High density lipteincholesterol,HDL-C)、低密度脂蛋白胆固醇(Low density lipteincholesterol,LDL-C)]、血清炎性因子[白细胞介素-6(Interleukin-6,IL-6)、C反应蛋白(C-reaction protein,CRP)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)]水平、左心功能(Ejection fraction,EF)及血管内皮功能[血清一氧化氮(Nitric Oxide,NO)、内皮素(Endothelin,ET)]。结果治疗后治疗组心电图有效率87.50%(49/56)明显高于对照组73.21%(41/56),差异有统计学意义(Z=-2.459,P=0.014,P<0.05)。治疗后两组患者血液流变学指标均较治疗前下降,差异有统计学意义(P<0.05);且治疗组血液流变学指标较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者TC、TG、LDL-C水平均较治疗前下降,HDL-C水平均较治疗前升高,差异有统计学意义(P<0.05);且治疗组TC、TG、LDL-C水平均较对照组下降,HDL-C水平较对照组升高,差异有统计学意义(P<0.05)。治疗后两组患者hs-CRP、IL-6、TNF-α水平均较治疗前下降,差异有统计学意义(P<0.05);且治疗组hs-CRP、IL-6、TNF-α水平均较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组�Objective To observe the effect of self-made Yiqi Shuxiong Huoxue Recipe on vascular endothelial function and hemorheology in patients with coronary in-stent restenosisof qi deficiency and blood stasis type.Methods A total of 116 patients with coronary in-stent restenosis of qi deficiency and blood stasis type who were treated in Chinese Medicine Hospital of Puyangfrom April 2018 to August 2020 were selected and divided into a control group and a treatment group according to the random number table method.Fifty-eight patients in the control group were given conventional western medicine treatment,and 58 patients in the treatment group received the self-made Yiqi Shuxiong Huoxue Recipe on the basis of the control group.After 4 months of treatment,the effective effect of electrocardiogram(ECG),hemorheological indexes[plasma viscosity(PV),low-shearwhole blood viscosity(L-WBV),medium-shear whole blood viscosity(M-WBV),high-shear whole blood viscosity(H-WBV)],four blood lipid levels[total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoproteincholesterol(LDL-C)],serum levels of inflammatory factors[interleukin-6(IL-6),C-reaction protein(CRP),tumor necrosis factor-α(TNF-α)],ejection fraction(EF),and vascular endothelial function[nitric oxide(NO),endothelin(ET)].Results During the treatment process,2 patients in the control group withdrew from the treatment due to personal reasons,and 2 in the treatment group failed to tolerate the TCM treatment and dropped out.Finally,56 patients were included in each of the two groups.The effective rate of ECG in the treatment group was 87.50%(49/56),higher than 73.21%(41/56)in the control group,and the difference was statistically significant(Z=-2.459,P=0.014,P<0.05).After treatment,the hemorheological indexes and the levels of TC,TG,LDL-C,hs-CRP,IL-6,TNF-α,and ET in the two groups were decreased compared with those before treatment(all P<0.05),with the treatment group having more obvious reduction than the control group(P<0.05),andthe

关 键 词：自拟益气舒胸活血方 气虚血瘀 血管内皮功能 冠脉支架内再狭窄 血液流变学 

分 类 号：R541.4[医药卫生—心血管疾病]