甲苯磺酸瑞马唑仑与力蒙欣静脉麻醉对无痛结肠镜患者术后认知功能、苏醒质量的影响  

Effect of intr avenous anesthesia with remazolam tosylate and Limengxin on postoperative cognitive function and recovery quality in patients receiving painless colonoscopy

作　　者：李光建 张鹏 陈峰 Li Guangjian;Zhang Peng;Chen Feng(Yantai Yeda Hospital,Yantai Shandong 264006,China)

机构地区：[1]山东烟台业达医院,山东烟台264006

出　　处：《保健医学研究与实践》2022年第10期58-61,共4页Health Medicine Research and Practice

摘　　要：目的 探讨甲苯磺酸瑞马唑仑与力蒙欣静脉麻醉对无痛结肠镜患者术后认知功能、苏醒质量的影响,以期为临床相关诊治提供参考。方法 选取2021年1—8月在山东烟台业达医院行无痛结肠镜术的80例患者作为研究对象,采用随机数字表法将患者分为对照组和观察组,每组40例。给予对照组患者静脉注射1 ug/kg舒芬太尼,再静脉注射1.5 mg/kg力蒙欣。给予观察组患者静脉注射1 ug/kg舒芬太尼,再缓慢静脉注射0.2 mg/kg甲苯磺酸瑞马唑仑。比较2组患者给药直至完成操作时舒张压、心率、呼吸频次。比较2组患者麻醉前及苏醒时简易智能精神状态检查量表(MMSE)评分。比较2组患者苏醒时间。比较2组患者麻醉开始至苏醒1 h内不良反应发生情况。结果 2组患者麻醉前、麻醉后3 min、检查完毕时呼吸频次、舒张压、心率比较,差异无统计学意义(P>0.05)。麻醉前,2组患者MMSE评分比较,差异无统计学意义(P>0.05)。苏醒时,2组患者MMSE评分均低于麻醉前,而观察组高于对照组,差异均有统计学意义(P<0.05)。观察组患者苏醒时间为(6.85±0.35)min,短于对照组的(7.98±1.21)min,差异有统计学意义(P<0.05)。观察组患者不良反应发生率为2.50%,低于对照组的22.50%,差异有统计学意义(P<0.05)。结论 在实施无痛结肠镜检查时,给予力蒙欣与甲苯环酸瑞马唑仑静脉麻醉的效果相当,均可为结肠镜检查患者提供有效的镇静效果,但后者用药安全性更高,术后苏醒质量更好,值得推广应用。Objective To investigate the effects of intravenous anesthesia with remimazolam tosilate and Propofol Injectable Emulsion(Limengxin) on postoperative cognitive function and recovery quality in patients receiving painless colonoscopy, so as to provide a reference for clinical diagnosis and treatment. Methods Eighty patients who underwent painless colonoscopy in the Yantai Yeda Hospital from January to August 2021 were selected as the study subjects. The patients were assigned to the control group and the observation group by the random number table, with 40 cases in each group. Patients in the control group were given intravenous sufentanil 1 ug/kg followed by intravenous Limengxin 1.5 mg/kg. Patients in the observation group were given an intravenous injection of 1 ug/kg sufentanil,followed by a slow intravenous injection of 0.2 mg/kg remimazolam tosilate. Diastolic blood pressure, heart rate, and respiratory trequeney were compared between the 2 groups until the completion of the procedure. Mini-Mental State Examination(MMSE) scores were compared between the two groups before anesthesia and during recovery. Recovery time was compared between the 2 groups. Adverse reactions were compared between the 2 groups from the start of anesthesia to 1 h of recovery. Results There was no significant difference in respiration, diastolic blood pressure, and heart rate before anesthesia, 3 min after anesthesia, and at the end of examination between the two groups(P>0.05). Before anesthesia, there was no significant difference in MMSE score between the two groups(P>0.05). At recovery, the MMSE scores of patients in both groups were significantly lower than those before anesthesia, while those in the observation group were significantly higher than those in the control group(P<0.05). The recovery time of the observation group was(6.85±0.35) min, which was significantly shorter than that of the control group(7.98±1.21) min(P<0.05). The incidence rate of adverse reactions in the observation group was 2.50%, which was significant

关 键 词：无痛结肠镜 甲苯环酸瑞马唑仑 力蒙欣 麻醉 苏醒质量 认知功能 

分 类 号：R614[医药卫生—麻醉学]