“短刺法”对膝骨关节炎患者miR-140、miR-30水平表达的影响及影像学观察  

Effects of Close-to-Bone Needing on Expressions of miR-140 and miR-30 and Imaging Observation in Patients with KOA

作　　者：刘泉宏 李维科 苏茜 靳少峰 陈江 任毅 LIU Quanhong;LI Weike;SU Qian;JIN Shaofeng;CHEN Jiang;REN Yi(Hanzhong Hospital of TCM,Hanzhong 723000,China)

机构地区：[1]汉中市中医医院,陕西汉中723000

出　　处：《针灸临床杂志》2022年第10期26-30,共5页Journal of Clinical Acupuncture and Moxibustion

基　　金：陕西省中医药管理局青年培优项目,编号:2021-PY-008;陕西省汉中市中心医院一般项目,编号:YK2032。

摘　　要：目的:研究“短刺法”对膝骨关节炎(KOA)患者miR-140、miR-30水平表达的影响及膝关节MRI观察结果。方法:选取68例KOA患者,根据治疗手段不同分为治疗组和对照组,各34例。检测两组患者治疗前、治疗后1 d和治疗后14 d miR-140、miR-30水平,评定骨关节炎指数(WOMAC)、KOA严重指数(ISOA)和简明健康状况指数(SF-36),评估MRI影像学检查及临床总有效率。结果:与治疗前比较,两组患者治疗后1 d、14 d miR-140水平上升、miR-30水平降低和WOMAC评分降低,ISOA、SF-36评分升高,差异具有统计学意义(P<0.05);与对照组治疗后1 d、14 d相比,治疗组miR-140水平上升、miR-30水平降低和WOMAC评分降低,ISOA、SF-36评分升高(P<0.05);治疗组治疗后14 d总有效率高于对照组,差异具有统计学意义(P<0.05);治疗组治疗后膝关节MRI显示关节软骨得到显著改善。结论:“短刺法”可通过调节KOA患者miR-140、miR-30水平,修复受累关节软骨,起到缓解KOA患者关节疼痛、僵硬等症状从而改善肢体功能及生活质量,且疗效显著。Objective:To observe the effects of close-to-bone needling(CBN)on the expressions of miR-140 and miR-30 and MRI results in patients with knee osteoarthritis(KOA).Methods:68 patients with KOA were randomly divided into the treatment group and the control group,with 34 cases in each group.The levels of miR-140 and miR-30 were detected,the scores of WOMAC,ISOA and SF-36 were evaluated,MRI imaging and the total clinical efficacy were also assessed before the treatment,after 1 d and 14 d of the treatment in the two groups.Results:The level of miR-140 was increased,the level of miR-30 was decreased,the WOMAC score was decreased,and the scores of ISOA and SF-36 were increased after 1 d and 14 d of the treatment compared with those before the treatment in the two groups(P<0.05).The level of miR-140 was increased,the level of miR-30 was decreased,the WOMAC score was lower,and the scores of ISOA and SF-36 were higher in the treatment group than those in the control group after 1 d and 14 d of the treatment(P<0.05).The total effective rate of the treatment group was higher than that of the control group after 14 days of the treatment(P<0.05).The MRI of the knee joint showed significant improvement of articular cartilage in the treatment group.Conclusion:CBN can significantly repair the damaged cartilage to relieve pain and stiffness of KOA by regulating the expressions of miR-140 and miR-30,it can also improve limb function and life quality of the patients with its significant effect.

关 键 词：短刺法 膝骨关节炎 微小核糖核酸 影像学 

分 类 号：R246.2[医药卫生—针灸推拿学]