雌孕激素序贯疗法联合Foley球囊干预预防胎物残留术后宫腔粘连的效果  

Effect of estrogen-progesterone sequential therapy combined with Foley balloon intervention on prevention of intrauterine adhesions after fetal residue surgery

作　　者：黄艳 李留霞[2] HUANG Yan;LI Liuxia(Huiji District People's Hospital,Zhengzhou 450000;the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州市惠济区人民医院,河南郑州450000 [2]郑州大学第一附属医院,河南郑州450000

出　　处：《临床医学研究与实践》2022年第30期24-26,共3页Clinical Research and Practice

基　　金：河南省医学科技攻关计划项目(No.2017T12121)。

摘　　要：目的探讨雌孕激素序贯疗法联合Foley球囊干预预防胎物残留术后宫腔粘连的效果。方法选取2019年6月至2021年1月郑州市惠济区人民医院妇科收治的108例胎物残留患者作为研究对象,采用随机数字表法将其分为对照组(54例,雌孕激素序贯疗法)和观察组(54例,雌孕激素序贯疗法+Foley球囊干预)。比较两组的治疗效果。结果观察组的疗效分级优于对照组,治疗总有效率高于对照组,粘连发生率低于对照组,术后阴道流血时间、月经恢复正常时间短于对照组(P<0.05)。术后3个月,观察组的子宫内膜厚度大于对照组,搏动指数(PI)、阻力指数(RI)小于对照组(P<0.05)。术后3个月,观察组的血清核因子-κB(NF-κB)、Snail水平低于对照组,差异具有统计学意义(P<0.05)。结论雌孕激素序贯疗法联合Foley球囊干预预防胎物残留术后宫腔粘连的临床效果显著,可促进患者康复。Objective To investigate the effect of estrogen-progesterone sequential therapy combined with Foley balloon intervention on prevention of intrauterine adhesions after fetal residue surgery.Methods A total of 108 patients with fetal residue admitted in gynecology department of Huiji District People’s Hospital from June 2019 to January 2021 were selected as the research objects,and the patients were divided into control group(54 cases,estrogen-progesterone sequential therapy)and observation group(54 cases,estrogen-progesterone sequential therapy+Foley balloon intervention)by random number table method.The treatment effects of the two groups were compared.Results The curative effect classification in the observation group was better than that in the control group,the total effective rate of treatment was higher than that in the control group,the incidence of adhesion was lower than that in the control group,and the postoperative vaginal bleeding time and menstrual recovery time were shorter than those in the control group(P<0.05).At 3 months after operation,the endometrial thickness in the observation group was greater than that in the control group,and the pulsatility index(PI)and resistance index(RI)were lower than those in the control group(P<0.05).At 3 months after operation,the serum nuclear factor-κB(NF-κB)and Snail levels in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Estrogen-progesterone sequential therapy combined with Foley balloon intervention on prevention of intrauterine adhesions after fetal residue surgery has a significant effect,it can promote the recovery of patients.

关 键 词：胎物残留术 Foley球囊 雌孕激素序贯疗法 宫腔粘连 子宫内膜厚度 

分 类 号：R713.4[医药卫生—妇产科学]