通督醒脑针法治疗颅脑损伤后意识障碍患者的效果及对意识状态、神经因子的影响  

Effect of Tongdu Xingnao acupuncture in the treatment of patients with consciousness disorder after craniocerebral injury and its influences on consciousness state and nerve factors

作　　者：马亮 毕立杰 赵莉莎 郝珊珊 MA Liang;BI Lijie;ZHAO Lisha;HAO Shanshan(Xi'an TCM Hospital of Encephalopathy,Xi'an 710032;Shaanxi Zhenghe Hospital,Xi'an 710054,China)

机构地区：[1]西安中医脑病医院,陕西西安710032 [2]陕西正和医院,陕西西安710054

出　　处：《临床医学研究与实践》2022年第30期120-124,共5页Clinical Research and Practice

摘　　要：目的 探讨通督醒脑针法治疗颅脑损伤后意识障碍患者的效果及对意识状态、神经因子的影响。方法 选取2016年6月至2021年3月我院收治的60例颅脑损伤后意识障碍患者作为研究对象,按照随机数字表法将其分为与对照组与观察组,各30例。对照组实施常规促醒法治疗,观察组在对照组基础上实施通督醒脑针法治疗。比较两组的治疗效果。结果 观察组的治疗总有效率明显高于对照组(P<0.05)。观察组的清醒时间、经口进食时间、下床活动时间、出院时间均短于对照组(P<0.05)。治疗后,观察组的修订版昏迷恢复量表(CRS-R)、全面无反应性量表(FOUR)评分均高于对照组(P<0.05)。治疗后,观察组的神经元特异性烯醇化酶(NSE)、星形胶质源性蛋白(S100β)水平均低于对照组,脑源性神经营养因子(BDNF)、神经生长因子(NGF)水平均高于对照组(P<0.05)。观察组的并发症总发生率明显低于对照组(P<0.05)。结论 通督醒脑针法治疗颅脑损伤后意识障碍患者效果显著,可显著促进患者康复,改善其意识状态,调节神经因子水平,减少并发症的发生。Objective To explore the effect of Tongdu Xingnao acupuncture in the treatment of patients with consciousness disorder after craniocerebral injury and its influences on consciousness state and nerve factors. Methods A total of 60 patients with consciousness disorder after craniocerebral injury admitted in our hospital from June 2016 to March 2021 were selected as the research objects, and the patients were divided into control group and observation group according to the random number table method, with 30 cases in each group. The control group was treated with routine awakening therapy, and the observation group was treated with Tongdu Xingnao acupuncture on the basis of the control group. The therapeutic effects of the two groups were compared. Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05). The awake time, oral feeding time, off-bed ambulation time and discharge time of the observation group were shorter than those of the control group(P<0.05). After treatment, the scores of modified Coma Recovery Scale-Revised(CRS-R) and Full Outline of Unresponsivenes(FOUR) in the observation group were higher than those in the control group(P<0.05). After treatment, the levels of neuron-specific enolase(NSE) and astrocyte-derived protein(S100β) in the observation group were lower than those in the control group,and the levels of brain-derived neurotrophic factor(BDNF) and nerve growth factor(NGF) were higher than those in the control group(P<0.05). The total incidence of complications in the observation group was significantly lower than that in the control group(P<0.05). Conclusion Tongdu Xingnao acupuncture in the treatment of patients with consciousness disorder after craniocerebral injury has a significant effect, which can significantly promote the recovery of patients, improve consciousness state, regulate the levels of nerve factors and reduce the occurrence of complications.

关 键 词：通督醒脑针法 颅脑损伤 意识障碍 意识状态 神经因子 

分 类 号：R26[医药卫生—中医外科学]