低温氧气雾化在放射性口腔黏膜炎患者的应用  

Effectiveness of low-temperature oxygen atomization inhalation on radiation-induced oral mucositis in patients with nasopharyngeal carcinoma

作　　者：欧娜 綦三阳 胡小萍 谭荆星 熊蓉 Ou Na;Qi Sanyang;Hu Xiaoping;Tan Jingxing;Xiong Rong(Department of Oncology,Affiliated Nanhua Hospital,University of South China,Hengyang 421000,China)

机构地区：[1]南华大学衡阳医学院附属南华医院肿瘤一科,湖南衡阳421000 [2]衡阳市第二人民医院老年康复科 [3]南华大学衡阳医学院附属南华医院护理部 [4]南华大学护理学院

出　　处：《护理学杂志》2022年第20期60-63,共4页Journal of Nursing Science

基　　金：湖南省卫生健康委员会一般指导性项目(202114011133)。

摘　　要：目的探讨低温氧气雾化吸入在鼻咽癌患者放射性口腔黏膜炎中的防治效果。方法将101例接受放疗的鼻咽癌患者按照整群随机法分为对照组(54例)和干预组(47例)。放疗期间,两组均以生理盐水和粒细胞刺激因子150μg为雾化液,每日进行2次雾化,每次持续吸入20 min。对照组接受常温超声雾化吸入,干预组接受低温氧气雾化吸入。结果干预组放射性口腔黏膜炎的严重程度以及持续时间显著轻于或短于对照组,而出现时间、唾液流量长于或高于对照组(均P<0.05)。但两组放射性口腔黏膜炎的发生率及在放射剂量达33 Gy时的口腔pH值比较,差异无统计学意义(均P>0.05)。结论低温氧气雾化可减轻鼻咽癌放疗患者放射性口腔黏膜炎的严重程度,延缓放射性口腔黏膜炎的出现并缩短病程,同时在保护口腔唾液腺、维持口腔内环境方面也有一定的效果。Objective To investigate the prevention and treatment effect of low-temperature oxygen atomization inhalation(LTOAI)in patients with nasopharyngeal carcinoma with radiation-induced oral mucositis(RIOM).Methods A total of 101 patients with nasopharyngeal carcinoma who received radiotherapy were randomly divided into an intervention group(n=47)and a control group(n=54).During radiotherapy,the two group received inhalation therapy with a mixture of saline and 150μg granulocyte colony stimulating factor(G-CSF).The control group was subjected to room temperature ultrasonic atomization inhalation(RTUAI),while the intervention group to LTOAI.Results There were significant differences in the severity of RIOM,the duration of RIOM,the time to RIOM onset,and saliva flow rate(SFR)between the 2 groups,with all outcomes favoring the intervention group(all P<0.05).However,there was no significant difference in the incidence rate of RIOM and oral pH value when the radiation dose reached 33 Gy,between the two groups(P>0.05 for both).Conclusion LTOAI can mitigate RIOM in nasopharyngeal carcinoma patients receiving radiation therapy,delay the onset and shorten the duration of RIOM.Meanwhile,LTOAI plays some role in protecting the saliva glands and maintaining the internal environment of the oral cavity.

关 键 词：鼻咽癌 放疗 低温氧气雾化吸入 放射性口腔黏膜炎 口腔PH值 唾液流量 

分 类 号：R473.76[医药卫生—护理学]