白细胞介素-38的生物学特性及其在自身免疫性疾病中作用的研究进展  

Research progress on biological characteristics of interleukin-38 and its role in autoimmune diseases

作　　者：代宛蓉 张宇 马莉 DAI Wanrong;ZHANG Yu;MA Li(School of Clinical Laboratory Science,Guizhou Medical University,Guizhou Province,Guiyang550004,China;Center for Clinical Laboratory,the Affiliated Hospital of Guizhou Medical University,Guizhou Province,Guiyang550004,China)

机构地区：[1]贵州医科大学医学检验学院,贵州贵阳550004 [2]贵州医科大学附属医院临床检验中心,贵州贵阳550004

出　　处：《中国医药导报》2022年第28期54-58,共5页China Medical Herald

基　　金：贵州省科技计划项目(黔科合平台人才[2019]5610号)。

摘　　要：白细胞介素(IL)-38是新近发现的一种抗炎细胞因子,属于IL-1家族成员,可广泛表达于人类多种细胞和组织中,其基因序列与IL-1受体拮抗剂(IL-1Ra)和IL-36受体拮抗剂(IL-36Ra)的编码基因高度同源,因而呈现类似IL-1Ra和IL-36Ra的拮抗作用。IL-38可作用于多种免疫细胞,影响细胞因子的分泌,在机体免疫反应的调节中发挥重要作用。研究表明,IL-38与多种自身免疫性疾病的发生、发展密切相关,有望成为这些疾病未来临床治疗中的潜在靶点。IL-38的作用机制复杂,涉及特异性受体募集、调控辅助性T细胞17分化等过程,深入了解IL-38在自身免疫性疾病中的作用有助于进一步探索其在疾病诊断和治疗中的应用价值。本文将对IL-38的生物学特性及其在自身免疫性疾病中作用的最新研究成果作一综述。Interleukin(IL)-38 is a newly discovered anti-inflammatory cytokine and a member of the IL-1 family,which can be widely expressed in a variety of human cells and tissues.Its gene sequence is highly homologous to the genes encoding IL-1 receptor antagonist(IL-1Ra)and IL-36 receptor antagonist(IL-36Ra).Thus,the antagonism of IL-1Ra and IL-36Ra was similar.IL-38 can act on a variety of immune cells,affect the secretion of cytokines,and play an important role in the regulation of immune response.Studies have shown that IL-38 is closely related to the occurrence and development of a variety of autoimmune diseases,which is expected to become a potential target in the future clinical treatment of these diseases.The mechanism of IL-38 is complex,involving the recruitment of specific receptors and the regulation of T helper cell 17 differentiation.A deeper understanding of the role of IL-38 in autoimmune diseases will help further explore its application value in the diagnosis and treatment of diseases.In this review,the biological characteristics of IL-38 and its role in autoimmune diseases are reviewed.

关 键 词：白细胞介素-38 自身免疫性疾病 辅助性T细胞17 白细胞介素1受体拮抗剂 白细胞介素36受体拮抗剂 

分 类 号：R446.69[医药卫生—诊断学]