泻肝凉血解毒方治疗寻常性银屑病血热证的效果  

Effect of Xiegan Liangxue Jiedu Decoction in the treatment of psoriasis vulgaris with blood heat syndrome

作　　者：吴孙思 程塞渊[1] 高尚璞[1] 李咏梅[1] 杨波[1] WU Sunsi;CHENG Saiyuan;GAO Shangpu;LI Yongmei;YANG Bo(Department of Dermatology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai200032,China)

机构地区：[1]上海中医药大学附属龙华医院皮肤科,上海200032

出　　处：《中国医药导报》2022年第28期140-143,共4页China Medical Herald

基　　金：上海市进一步加快中医药事业发展三年行动计划中医重点专科培育项目[ZY(2018-2020)-FWTX-7001];上海市龙华医院中医适宜技术提升项目(YW.005.010)。

摘　　要：目的观察寻常性银屑病血热证经泻肝凉血解毒方治疗的效果。方法选取2020年1月至2021年3月上海中医药大学附属龙华医院收治的寻常性银屑病患者80例,根据随机数字表法将其分为研究组(40例,泻肝凉血解毒方联合卡泊三醇软膏治疗)和对照组(40例,复方青黛胶囊联合卡泊三醇软膏治疗)。两组治疗周期均为8周。比较两组疗效,比较两组治疗前后银屑病皮损面积及严重程度指数(PASI)、中医证候积分及血清白细胞介素(IL)-17、IL-22、IL-23。记录两组治疗期间不良反应发生情况。结果研究组疗效优于对照组,差异有统计学意义(P<0.05)。治疗后,两组PASI、中医证候积分及血清IL-17、IL-22、IL-23水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。两组治疗期间均未见明显不良反应发生。结论泻肝凉血解毒方治疗寻常性银屑病血热证效果显著,可有效改善症状,同时还可降低患者IL-17、IL-22、IL-23水平。Objective To observe the effect of Xiegan Liangxue Jiedu Decoction in the treatment of psoriasis vulgaris with blood heat syndrome.Methods A total of 80 patients with psoriasis vulgaris treated in Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2020 to March 2021 were selected and divided into study group(40 cases,Xiegan Liangxue Jiedu Decoction combined with Caspotriol Ointment)and control group(40 cases,Compound Qingdai Capsules combined with Caspotriol Ointment)according to the random number table method.The treatment period of both groups was eight weeks.The efficacy of the two groups was compared.The psoriasis area and severity index(PASI),traditional Chinese medicine syndrome score,and serum interleukin(IL)-17,IL-22,and IL-23 were compared between the two groups before and after treatment.The incidence of adverse reactions during treatment was recorded in the two groups.Results The efficacy of the study group was better than that of the control group,and the difference was statistically significant(P<0.05).After treatment,PASI,traditional Chinese medicine syndrome score,and serum levels of IL-17,IL-22,and IL-23 in the two groups were lower than those before treatment,and the study group was lower than the control group,and the differences were statistically significant(P<0.05).There were no obvious adverse reactions in the two groups during treatment.Conclusion Xiegan Liangxue Jiedu Decoction has significant effect in the treatment of psoriasis vulgaris with blood heat syndrome,which can effectively improve the symptoms and reduce the levels of IL-17,IL-22,and IL-23 in patients.

关 键 词：泻肝凉血解毒方 寻常性银屑病 血热证 疗效 机制 

分 类 号：R275[医药卫生—中医皮科]