合并及非合并间质性肺病的RA、DM/PM、SSc患者血清TGF-β1和SP-D水平对比观察  

Comparison of serum TGF-β1 and SP-D levels between RA,DM/PM,and SSc patients with and without interstitial lung disease

作　　者：蒋真[1,2] 李向培 刘娟 白文花[2] JIANG Zhen;LI Xiangpei;LIU Juan;BAI Wenhua(Department of Immunology and Rheumatology,The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University,Huaian 223300,China)

机构地区：[1]南京医科大学附属淮安市第一人民医院免疫风湿科,江苏淮安223300 [2]徐州医科大学附属淮安医院免疫风湿科 [3]中国科学技术大学附属安徽省立医院风湿科

出　　处：《山东医药》2022年第24期14-17,共4页Shandong Medical Journal

基　　金：江苏省卫健委“六个一工程”拔尖人才科研项目(LGY2019050);江苏省卫健委“333”人才课题(BRA2020226)。

摘　　要：目的对比观察合并及非合并间质性肺病(ILD)的类风湿关节炎(RA)、皮肌炎/多发性肌炎(DM/PM)、系统性硬化症(SSc)患者血清转化生长因子β(TGF-β)和表面活性蛋白D(SP-D)水平。方法选取结缔组织病(CTD)患者64例,包括RA 12例[合并ILD(RA-ILD)5例、非合并ILD 7例]及DM/PM 26例[合并ILD(DM/PM-ILD)19例、非合并ILD 7例]和SSc 26例[合并ILD(SSc-ILD)22例、非合并ILD 4例],采用ELISA法检测血清TGF-β、SP-D。结果RA、DM/PM、SSc患者血清TGF-β和SP-D水平比较均无统计学差异,P均>0.05。与RA非合并ILD者比较,DM/PM非合并ILD者、SSc非合并ILD者血清TGF-β水平降低(P均<0.05);与CTD-ILD者比较,CTD非合并ILD者血清SP-D水平降低(P<0.05);与RA-ILD者比较,RA非合并ILD血清TGF-β水平升高、血清SP-D水平降低(P均<0.05)。结论合并及非合并ILD的RA、DM/PM、SSc患者血清TGF-β和SP-D水平存在差异,检测两指标有助于不同CTD-ILD的病情判断。Objective To compare the serum transforming growth factorβ(TGF-β)and surfactant protein D(SPD)levels in rheumatoid arthritis(RA),dermatomyositis/polymyositis(DM/PM),and systemic sclerosis(SSc)patients with and without interstitial lung disease(ILD).Methods Sixty-four inpatients with different connective tissue diseases(CTDs)were involved in the present study,which included 12 cases of RA[5 cases with ILD(RA-ILD),7 cases without ILD],26 cases of DM/PM[19 cases with ILD(DM/PM-ILD),7 cases without ILD],and 26 cases of SSc[22 cases with ILD(SSc-ILD),4 cases without ILD].We used ELISA to detect serum TGF-βand SP-D levels.Results There were no significant differences in the levels of serum TGF-βor SP-D in patients with RA,DM/PM,and SSc(all P>0.05).Compared with RA patients without ILD,serum TGF-βlevels decreased in DM/PM patients without ILD and SSc patients without ILD(all P<0.05).Compared with CTD-ILD patients,the serum SP-D decreased in CTD patients without ILD(P<0.05).Compared with RA-ILD patients,serum TGF-βlevel increased and serum SP-D level decreased in RA patients without ILD(both P<0.05).Conclusions There are significant differences in levels of TGF-βand SP-D between RA,DM/PM,and SSc patients with and without ILD.Detection of the two indicators is helpful for the diagnosis of different CTD-ILD.

关 键 词：结缔组织病 间质性肺病 类风湿关节炎 皮肌炎 多发性肌炎 系统性硬化症 转化生长因子β1 表面活性蛋白D 

分 类 号：R593.2[医药卫生—内科学]