基于中医传承辅助平台挖掘专利数据库中治疗围绝经期综合征的用药规律  

Based on traditional Chinese medicine(TCM)inheritance auxiliaryplatform to minemedication rules for treatment of peripheral menopause syndrome in patent database

作　　者：杨雅琪 冯浩妍 江玲 李莉[1,2] YANG Yaqi;FENG Haoyan;JIANG Ling;LI Li(First Clinical School of Medicine,Guangzhou University of Traditional Chinese Medicine,Guangzhog 510000,China;Department of Gynecology,the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhog 510000,China)

机构地区：[1]广州中医药大学第一临床医学院,广州510000 [2]广州中医药大学第一附属医院妇科,广州510000

出　　处：《新疆医科大学学报》2022年第10期1201-1207,共7页Journal of Xinjiang Medical University

基　　金：广东省中医药局科研项目(20212063)。

摘　　要：目的分析中药复方治疗围绝经期综合征(peripheral menopause syndrome,PMS)患者的用药配伍规律,为中药新方研发和临床使用提供依据。方法以国家知识产权局专利检索及分析系统为数据来源,检索治疗PMS的中药复方;采用中医辅助传承平台(V2.5)建立数据库,并进行频次统计、中药四气五味及归经统计、关联分析、复杂网络及熵层次聚类分析,采用SPSS 25.0软件进行主成分分析。结果纳入1999-2021年治疗PMS的中药复方专利194首,使用中药315味;最常用单味药为当归,高频药物归经以肝、肾二经为主,功效多为补血、清热、补阳、补阴药物;最常用的药对为当归-白芍及熟地-当归,最常用的角药为当归-白芍-茯苓;关联规则中置信度最高的为“黄柏,淫羊藿→知母”;熵层次聚类分析,共得到22组药物组合,11组新处方聚类组合;主成分分析获得特征值>1的主成分有12个。结论PMS患者多为阴阳两虚而以阴虚为主,治以补益肝肾、平衡阴阳为法,用药以归芍地黄丸合二仙汤为底方加减,配伍使用多归属肝、肾二经的安神、收涩、利水渗湿等药物,同时多用知母、黄柏之苦寒泻火坚阴,亦多用龙骨、牡蛎之咸寒重镇潜阳。Objective To analyze the drug compatibility rules of traditional Chinese medicine(TCM)compound prescriptions in treatment of perimenopausal syndrome,and provide reference fordevelopment and clinical application of new TCM prescriptions.Methods Using the Patent Retrieval and Analysis System of the State Intellectual Property Office as the data source,TCM compound prescriptions for treatment of perimenopausal syndrome were searched;the database was established by TCM auxiliary inheritance platform(V2.5),and frequency statistics,four qi and five flavors of TCM and the return were collected.After statistics,correlation analysis,complex network and entropy hierarchical cluster analysis,SPSS 25.0 software was used for principal component analysis.Results194 Chinese medicine compound patents from 1999 to 2021 were included,and 315 Chinese medicines were used.The most commonly used single medicine was angelica sinensis.The high-frequency medicine was mainly based on liver and kidney meridian,and its effects were mostly blood tonic,heat-clearing,Yang tonic and Yin tonic.The most commonly used in drug pairs were angelica sinensis-paeony and mature ground-Angelica Sinensis,and the most commonly used in horn drug was Angelica Sinensis-Paeony-Poria Cocos.Among the association rules,the highest confidence was“Phellodendron Chinense,Epimedium→Anemone”.A total of 22 groups of drug combinations and 11 groups of new prescription clusters were obtained by entropy hierarchical clustering analysis.Principal component analysis showed that there were 12 principal components with eigenvalue>1.ConclusionPatients with PMS are two empty and given priority to with Yin deficiency of Yin and Yang,tonic liver and kidney,with balancing Yin and Yang as the method of cure.The medication is based on Guishao Dihuang pill and Erxian Decoction,which is combined with drugs belonging to the liver and kidney meridian,such as soothing the mind,astringent,and improving water infiltration,etc.At the same time,it is used for the bitter cold diarrhea o

关 键 词：围绝经期综合征 中药专利 用药规律 数据挖掘 传承辅助平台 

分 类 号：R259[医药卫生—中西医结合]