西格列汀联合优泌乐25治疗2型糖尿病对胰岛素抵抗、心肌纤维化及核转录因子-κB水平的影响  

Effects of sitagliptin combined with Humalog 25 in treatment of T2DM on insulin resistance,myocardial fibrosis and NF-κB level

作　　者：汤小峰 管义祥 Tang Xiaofeng;Guan Yixiang(Department of Endocrinology,Rugao People’s Hospital Affiliated to Nantong University,Rugao 226500,China)

机构地区：[1]南通大学附属如皋人民医院内分泌科,江苏如皋226500 [2]海安市人民医院神经外科

出　　处：《海军医学杂志》2022年第9期955-958,共4页Journal of Navy Medicine

基　　金：江苏省卫生计生委科研课题(Z2019033)。

摘　　要：目的探讨西格列汀联合优泌乐25治疗2型糖尿病(T2DM)对胰岛素抵抗(IR)、心肌纤维化及核转录因子-κB(NF-κB)的影响。方法选取2018年4月至2021年4月南通大学附属如皋人民医院内分泌科收治的120例T2DM患者为研究对象,通过简单随机数字表法分为研究组和对照组,各60例。对照组患者予以优泌乐25治疗,研究组患者在对照组基础上联合西格列汀治疗,2组均治疗3个月。比较2组患者治疗前后空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)、B型脑钠肽(BNP)、半乳糖凝集素-3(Gal-3)、组织金属蛋白酶抑制剂-1(TIMP-1)及NF-κB水平,并记录不良反应发生情况。结果治疗前,2组患者FBG、2 h PG、HbAlc、HOMA-IR、BNP、Gal-3、TIMP-1及NF-κB水平比较,差异无统计学意义(P>0.05)。治疗后,2组患者FBG、2 h PG、HbAlc、HOMA-IR、BNP、Gal-3及NF-κB水平均低于治疗前,且研究组低于对照组,而TIMP-1水平均高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。2组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论西格列汀联合优泌乐25治疗T2DM可明显改善IR情况及NF-κB水平,延缓心肌纤维化进程,且不良反应发生率低,值得临床应用。Objective To explore the effects of sitagliptin combined with Humalog 25 in treatment of type 2 diabetes(T2DM)on insulin resistance(IR),myocardial fibrosis and nuclear factor-κB(NF-κB).Methods 120 patients with T2DM admitted to the Endocrinology Department of Rugao People’s Hospital Affiliated to Nantong University from April 2018 to April 2021 were enrolled as research subjects,and were randomly divided into the study group and the control group,each consisting of 60.The patients in the control group were treated with Humalog 25,while the patients in the study group were treated with sitagliptin on the basis of the control group,for a treatment course of 3 months.The levels of fasting blood glucose(FBG),2 h postprandial blood glucose(2 h PG),glycosylated hemoglobin(HbAlc),insulin resistance(HOMA-IR),B-type brain natriuretic peptide(BNP),galectin-3(Gal-3),tissue inhibitor of metalloproteinase-1(TIMP-1)and NF-κB were compared between the patients of the two groups before and after treatment,and the rate of adverse reactions was also recorded in the process.Results There was no statistical significance in the levels of FBG,2 h PG,HbAlc,HOMA-IR,BNP,Gal-3,TIMP-1 and NF-κB before treatment,when comparisons were made between the patients of the two groups(P>0.05).After treatment,the levels of FBG,2 h PG,HbAlc,HOMA-IR,BNP,Gal-3 and NF-κB in the patients of the two groups were all lower than those before treatment,with the levels of the study group being lower than those of the control group,while the TIMP-1 level was higher than that before treatment,with the levels of the study group being higher than that of the control group,and statistical significance could be noted when comparisons were made between the 2 groups(P<0.05).There was no statistical significance in the total rate of adverse reactions,when comparisons were made between the patients of the two groups(P>0.05).Conclusion Sitagliptin combined with Humalog 25 in treatment of T2DM could significantly improve IR and NF-κB levels,delay the process of my

关 键 词：西格列汀 优泌乐25 2型糖尿病 胰岛素抵抗 心肌纤维化 核转录因子-ΚB 

分 类 号：R453[医药卫生—治疗学]