沙门氏菌中主要毒力因子的研究进展  

Research Progress of Main Virulence Factors in Salmonella

作　　者：刘理慧 储锦华 隋雨欣 陈杨[1] 程古月[1,2] LIU Li-hui;CHU Jin-hua;SUI Yu-xin;CHEN Yang;CHENG Gu-yue(MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products,Huazhong Agricultural University,Wuhan 430070;National Reference Laboratory of Veterinary Drug Residues(HZAU)and MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods,Huazhong Agricultural University,Wuhan 430070)

机构地区：[1]华中农业大学农业部畜禽产品质量安全风险评估实验室(武汉),武汉430070 [2]华中农业大学国家兽药残留基准实验室(HZAU)农业部食品兽药残留检测重点实验室,武汉430070

出　　处：《生物技术通报》2022年第9期72-83,共12页Biotechnology Bulletin

基　　金：国家自然科学基金项目(32072921)。

摘　　要：沙门氏菌是一种最常见的食源性致病菌,是全球细菌性胃肠炎的主要病因之一。其血清型众多,目前已报道超过2 600种,不同血清型沙门氏菌对人和动物的致病性不同。其致病性与毒力因子密切相关。本文系统介绍了沙门氏菌主要的毒力因子以及各自编码的分泌系统和/或毒力基因及其功能,进一步分析了毒力基因与毒力的关系,同时讨论了全基因组测序(WGS)预测毒力水平的可行性,有助于探究沙门氏菌中各种毒力因子与宿主相互作用的机制,从基因层面上理解沙门氏菌病,在源头上控制沙门氏菌,从而为沙门氏菌病预防和治疗提供新思路。Salmonella is one of the most common foodborne pathogens and is one of the leading causes of bacterial gastroenteritis worldwide.Its serotypes are numerous,more than 2 600 ones have been reported,and different serotypes of Salmonella have different pathogenicity in humans and animals.Its pathogenicity is closely related to virulence factors.In this paper,the main virulence factors,secretion systems and/or virulence genes encoded by Salmonella and their functions are systematically introduced,the relationship between virulence genes and virulence is further analyzed,and the feasibility of whole genome sequencing(WGS)in predicting virulence levels is also discussed.It is conducive to exploring the mechanism of interaction between various virulence factors and the host in Salmonella,to understanding salmonellosis at the genetic level and facilitating the control of Salmonella at the source,thus providing new ideas for the prevention and treatment of salmonellosis.

关 键 词：沙门氏菌毒力岛 沙门氏菌毒力质粒 结构性毒力因子 肠毒素 毒力因子 

分 类 号：S852.61[农业科学—基础兽医学]