基于生物材料构建人工真皮支架的研究进展  

Research advances on the construction of artificial dermal scaffolds based on biomaterials

作　　者：陈继秋 朱世辉 Chen Jiqiu;Zhu Shihui(Department of Burn Surgery,the First Affiliated Hospital of Naval Medical University,Burn Institute of PLA,Shanghai 200433,China)

机构地区：[1]海军军医大学第一附属医院烧伤外科,全军烧伤研究所,上海200433

出　　处：《中华烧伤与创面修复杂志》2022年第10期968-972,共5页Chinese Journal of Burns And Wounds

基　　金：国家重点研发计划(2019YFA0110603)。

摘　　要：在创面修复领域中,无瘢痕愈合以及完整重建皮肤功能是临床及基础研究面临的重大挑战。目前,已有多种人工真皮支架被用于临床创面修复,以解决组织缺损导致的皮肤结构失调等问题。皮肤组织工程研究中用于制作人工真皮支架的生物材料主要包括天然生物材料、生物合成材料以及有机高分子材料这3类。该文综述了生物材料的生物相容性、生物活性、可降解性及生物材料对创面愈合的作用,并概述了基于生物材料、创面愈合细胞及相关细胞因子的人工真皮支架构建策略。In the field of wound repair,scarless healing and complete reconstruction of skin function are major challenges in clinical and basic research.At present,a variety of artificial dermal scaffolds have been used in the clinical repair of wounds to overcome the problems such as skin structural disorders caused by tissue defects.The biomaterials used to make artificial dermal scaffolds in skin and tissue engineering research mainly include three categories:natural biomaterials,biosynthetic materials,and organic polymer materials.This review summarizes the biocompatibility,bioactivity,and degradability of biomaterials and their effects on wound healing,and provides an overview of artificial dermal scaffold construction strategies based on biomaterials,wound healing cells,and associated cytokines.

关 键 词：生物相容性材料 组织支架 组织工程 皮肤 创面修复 细胞生物修饰 生长因子修饰 

分 类 号：R318.08[医药卫生—生物医学工程]