天然与重组胶原蛋白在创面修复中的应用研究进展  

Research advances on the application of natural and recombinant collagen in wound repair

作　　者：刘小刚 陈蕾[1] 李海航 胡妍珂 熊雅慧 黄薇 苏沙沙 祁少海[1] Liu Xiaogang;Chen Lei;Li Haihang;Hu Yanke;Xiong Yahui;Huang Wei;Su Shasha;Qi Shaohai(Department of Burn and Wound Repair,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510062,China;School of Biomedical Engineering,Sichuan University,Chengdu 610065,China;Sun Yat-sen University-Yixian Group Skin Health Precision Research Joint Laboratory,Yue Keli Skin Regeneration Laboratory,Guangzhou 510275,China)

机构地区：[1]中山大学附属第一医院烧伤与创面修复科,广州510062 [2]四川大学生物医学工程学院,成都610065 [3]中山大学-逸仙集团皮肤健康精准研究联合实验室,悦可丽皮肤再生实验室,广州510275

出　　处：《中华烧伤与创面修复杂志》2022年第10期978-982,共5页Chinese Journal of Burns And Wounds

基　　金：广东省自然科学基金(2020B1515020049);中山大学附属第一医院“三个三”工程团队(Y70214)。

摘　　要：胶原蛋白是一种构成动物结缔组织细胞外基质的高分子蛋白质,在生物医学、组织工程、食品以及化妆品等领域均有着广泛的应用和发展。胶原蛋白由于来源丰富且具有良好的生物相容性、低免疫原性与可降解性等优点,可被用作敷料或组织工程支架用于创面修复。根据材料来源,胶原蛋白可被分为天然胶原蛋白和重组胶原蛋白,天然胶原蛋白主要是从哺乳动物和鱼类中直接提取的;而重组胶原蛋白是基于基因工程技术得到的,来源包括微生物、动物或植物重组表达体系。该文总结了胶原蛋白的来源及不同来源的胶原蛋白在创面修复中的作用及其优点、不足等,胶原蛋白结合三维打印技术用于创面修复的特殊性与优越性,以及中国胶原蛋白产业的市场规范对创面修复领域的影响,并对研发胶原蛋白相关产品的注意事项等做了进一步说明,旨在为选择合适来源的胶原蛋白进行创面修复提供新思路。Collagen is a macromolecular protein constituting the extracellular matrix of animal connective tissue,which has been widely used and developed in fields of biomedicine,tissue engineering,food,and cosmetics.Due to its advantages such as abundant sources and good biocompatibility,low immunogenicity,and degradability,collagen can be used as a dressing or tissue engineering scaffold for wound repair.According to the source of materials,collagen can be divided into natural collagen and recombinant collagen.Natural collagen is mainly extracted directly from mammals and fish;recombinant collagen is obtained based on genetic engineering technology,and its sources include recombinant expression systems of microorganisms,animals,and plants.This paper summarizes the sources of collagen,and the roles,advantages,and disadvantages of different sources of collagen in wound repair,the particularity and superiority of collagen combined with three-dimensional printing technology in wound repair,the impact of market norms of China's collagen industry on the field of wound repair,and explains the precautions for the development of collagen-related products,aiming to provide new ideas for selecting a suitable source of collagen for wound repair.

关 键 词：生物相容性材料 打印 三维 创面修复 天然胶原蛋白 重组胶原蛋白 市场规范 

分 类 号：R318.08[医药卫生—生物医学工程]