妇科养血颗粒联合屈螺酮炔雌醇治疗功能性子宫出血的临床研究  

Clinical study on Fuke Yangxue Granules combined with drospirenone and ethinylestradiol in treatment of functional uterine bleeding

作　　者：殷汝昌[1] 耿爱芝[1] 张春燕[1] YIN Ru-chang;GENG Ai-zhi;ZHANG Chun-yan(Department of Gynecology,the Second People’s Hospital of Liaocheng,Liaocheng 252600,China)

机构地区：[1]聊城市第二人民医院妇科,山东聊城252600

出　　处：《现代药物与临床》2022年第9期2098-2102,共5页Drugs & Clinic

摘　　要：目的探讨妇科养血颗粒联合屈螺酮炔雌醇治疗功能性子宫出血的临床疗效。方法选择2020年1月—2022年1月在聊城市第二人民医院诊疗的200例子宫出血者,随机分对照组(100例)和治疗组(100例)。对照组患者口服屈螺酮炔雌醇片,1片/次,1次/d。治疗组在对照组的基础上口服妇科养血颗粒,1袋/次,2次/d。两组治疗7周。观察两组患者临床疗效,比较治疗前后两组患者症状改善时间,性激素垂体分泌卵泡雌激素(FSH)、雌二醇(E2)、促黄体生成素(LH)和睾酮激素(T)水平,血清白细胞介素-2(IL-2)、血管内皮生长因子A(VEGFA)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平,及不良反应情况。结果治疗后,治疗组临床有效率明显高于对照组(98.00%vs 89.00%,P<0.05)。治疗后,治疗组症状改善时间均明显早于对照组(P<0.05)。治疗后,两组FSH水平明显升高,而E2、LH、T、IL-2、VEGFA、TNF-α、CRP水平明显降低(P<0.05),且治疗组性激素水平和血清炎性因子水平明显好于对照组(P<0.05)。治疗组不良发生率(7.00%)明显低于对照组(13.00%,P<0.05)。结论妇科养血颗粒联合屈螺酮炔雌醇治疗功能性子宫出血,可明显缩短止血时间,明显改善性激素水平,降低炎性因子,且安全有效。Objective To investigate the efficacy of Fuke Yangxue Granules combined with drospirenone and ethinylestradiol in treatment of functional uterine bleeding.Methods Patients(200 cases)with functional uterine bleeding in the Second People’s Hospital of Liaocheng from January 2020 to January 2022 were randomly divided into control(100 cases)and treatment(100 cases)group.Patients in the control group were po administered with Drospirenone and Ethinylestradiol Tablets,1 tablet/time,once daily.Patients in the treatment group were po administered with Fuke Yangxue Granules on the basis of the control group,1 bag/time,twice daily.Patients in two groups were treated for 7 weeks.After treatment,the clinical evaluation was evaluated,the improvement time of symptoms,the levels of hormone FSH,E2,LH and T,the levels of serum IL-2,VEGFA,TNF-αand CRP,and the adverse reactions in two groups before and after treatment were compared.Results After treatment,the clinical effective rate of the treatment group was significantly higher than that of the control group(98.00%vs 89.00%,P<0.05).After treatment,the improvement time of symptoms in the treatment group was significantly earlier than that in the control group(P<0.05).After treatment,the level of FSH was significantly increased in two groups,while the level of E2,LH,T,IL-2,VEGFA,TNF-αand CRP was significantly decreased(P<0.05),and the level of sex hormones and serum inflammatory factors in the treatment group were significantly better than those in the control group(P<0.05).the incidence of adverse reactions in the treatment group(7.00%)was significantly lower than that in the control group(13.00%,P<0.05).Conclusion Fuke Yangxue Granules combined with drospirenone and ethinylestradiol in treatment of functional uterine bleeding can significantly shorten the hemostatic time,significantly improve the level of sex hormones and reduce inflammatory factors,and is safe and effective.

关 键 词：妇科养血颗粒 屈螺酮炔雌醇片 功能性子宫出血 垂体分泌卵泡雌激素 雌二醇 促黄体生成素 血管内皮生长因子 C反应蛋白 

分 类 号：R984[医药卫生—药品]